Gene

mical3a

ID

ZDB-GENE-050126-2

Name

microtubule associated monooxygenase, calponin and LIM domain containing 3a

Symbol

mical3a Nomenclature History

Previous Names

mical3

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have FAD binding activity; actin binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in actin filament depolymerization. Predicted to localize to filamentous actin; microtubule organizing center; and nucleus. Is expressed in several structures, including cardiovascular system; pectoral fin; pectoral fin bud; proctodeum; and retina. Orthologous to human MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Xue et al., 2010

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mical3a Human Ortholog

No data available

Associated With mical3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001715	Calponin homology domain
Domain	IPR001781	Zinc finger, LIM-type
Domain	IPR002938	FAD-binding domain
Domain	IPR022735	bMERB domain
Family	IPR050540	F-actin Monooxygenase Mical
Homologous_superfamily	IPR036188	FAD/NAD(P)-binding domain superfamily
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Length	bMERB domain	Calponin homology domain	CH domain superfamily	F-actin Monooxygenase Mical	FAD-binding domain	FAD/NAD(P)-binding domain superfamily	Zinc finger, LIM-type
UniProtKB:A0A8M9PVP9 InterPro	2124
UniProtKB:A0A8M9PCY4 InterPro	2522
UniProtKB:A0A8M9PME7 InterPro	2154
UniProtKB:F1QH17 InterPro	1994

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mical3a-203 (1) Ensembl	Ensembl	589 nt	Select Tool
mRNA	mical3a-204 (1) Ensembl	Ensembl	3,541 nt	Select Tool
mRNA	mical3a-205 (1) Ensembl	Ensembl	5,985 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations