Gene
xgb
- ID
- ZDB-GENE-050125-1
- Name
- x globin
- Symbol
- xgb Nomenclature History
- Previous Names
-
- GbX1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables heme binding activity; nitrite reductase activity; and oxygen binding activity. Acts upstream of or within response to hypoxia. Located in membrane. Is expressed in several structures, including blood; cardiovascular system; digestive system; kidney; and nervous system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Globin | Globin-like Oxygen Transporters | Globin-like superfamily | Globin/Protoglobin |
|---|---|---|---|---|---|---|
| UniProtKB:A3KNI8 | InterPro | 200 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Pan, A., Liu, X., Han, H., Gao, S.Q., Lin, Y.W. (2025) Disruption of a potential disulfide bond of Cys65-Cys141 on the structure and stability of globin X from zebrafish. Physical chemistry chemical physics : PCCP. :
- Farhana, R., Lei, R., Pham, K., Derrien, V., Cedeño, J., Rodriquez, V., Bernad, S., Lima, F.F., Miksovska, J. (2022) Globin X: A highly stable intrinsically hexacoordinate globin. Journal of inorganic biochemistry. 236:111976
- Kim, S.H., Yang, D., Bae, Y.A. (2021) Hypoxic and nitrosative stress conditions modulate expression of myoglobin genes in a carcinogenic hepatobiliary trematode, Clonorchis sinensis. PLoS neglected tropical diseases. 15:e0009811
- Amdahl, M.B., Petersen, E.E., Bocian, K.A., Kaliszuk, S.J., DeMartino, A.W., Tiwari, S., Sparacino-Watkins, C.E., Corti, P., Rose, J.J., Gladwin, M.T., Fago, A., Tejero, J. (2019) The zebrafish Cytochrome b5/Cytochrome b5 reductase/NADH system efficiently reduces Cytoglobins 1 and 2 - Conserved activity of Cytochrome b5/Cytochrome b5 reductases during vertebrate evolution. Biochemistry. 58(29):3212-3223
- Amdahl, M.B., Sparacino-Watkins, C.E., Corti, P., Gladwin, M.T., Tejero, J. (2017) Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System.. Biochemistry. 56:3993-4004
- Corti, P., Xue, J., Tejero, J., Wajih, N., Sun, M., Stolz, D.B., Tsang, M., Kim-Shapiro, D.B., Gladwin, M.T. (2016) Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proceedings of the National Academy of Sciences of the United States of America. 113:8538-43
- Blank, M., and Burmester, T. (2012) Widespread occurrence of N-terminal acylation in animal globins and possible origin of respiratory globins from a membrane-bound ancestor. Mol. Biol. Evol.. 29(11):3553-3561
- Blank, M., Wollberg, J., Gerlach, F., Reimann, K., Roesner, A., Hankeln, T., Fago, A., Weber, R.E., and Burmester, T. (2011) A membrane-bound vertebrate globin. PLoS One. 6(9):e25292
- Tiedke, J., Gerlach, F., Mitz, S.A., Hankeln, T., and Burmester, T. (2011) Ontogeny of globin expression in zebrafish (Danio rerio). Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 181(8):1011-21
- Roesner, A., Mitz, S.A., Hankeln, T., and Burmester, T. (2008) Globins and hypoxia adaptation in the goldfish, Carassius auratus. The FEBS journal. 275(14):3633-3643
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