Gene
lats2
- ID
- ZDB-GENE-050119-6
- Name
- large tumor suppressor kinase 2
- Symbol
- lats2 Nomenclature History
- Previous Names
-
- si:ch211-173o4.2
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in BMP signaling pathway; convergent extension involved in gastrulation; and secondary heart field specification. Predicted to localize to nucleus and spindle pole. Is expressed in several structures, including nervous system; neural crest cell; non neural ectoderm; pectoral fin bud; and pleuroperitoneal region. Used to study peripheral nerve sheath neoplasm. Orthologous to human LATS2 (large tumor suppressor kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
peripheral nerve sheath neoplasm | lats2mw87/mw87 | standard conditions | Brandt et al., 2019 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR000961 | AGC-kinase, C-terminal |
Domain | IPR015940 | Ubiquitin-associated domain |
Family | IPR050236 | Serine/threonine-protein kinases, AGC |
Homologous_superfamily | IPR009060 | UBA-like superfamily |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
Protein | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC | UBA-like superfamily | Ubiquitin-associated domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:B0S8I4
|
1140 | ||||||||
UniProtKB:B2BJC0
|
1078 | ||||||||
UniProtKB:B2BJC1
|
1140 |
Interactions and Pathways
No data available
Plasmids
No data available