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Gene

lats2

ID
ZDB-GENE-050119-6
Name
large tumor suppressor kinase 2
Symbol
lats2 Nomenclature History
Previous Names
  • si:ch211-173o4.2
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of with a negative effect on BMP signaling pathway. Acts upstream of or within convergent extension involved in gastrulation and secondary heart field specification. Predicted to be active in nucleus and spindle pole. Is expressed in several structures, including nervous system; neural crest cell; non neural ectoderm; pectoral fin bud; and pleuroperitoneal region. Used to study peripheral nerve sheath neoplasm. Orthologous to human LATS2 (large tumor suppressor kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lats2 Human Ortholog
No data available
Associated With lats2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR015940 Ubiquitin-associated domain
Family IPR028742 Serine/threonine-protein kinase LATS2
Homologous_superfamily IPR009060 UBA-like superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase LATS2 UBA-like superfamily Ubiquitin-associated domain
UniProtKB:B2BJC0 1078
UniProtKB:A0A2R8QF71 1140
UniProtKB:B2BJC1 1140
UniProtKB:F1QGL3 1078
UniProtKB:A0A2R8QB11 1054
UniProtKB:B0S8I4 1140
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations