Gene

erbb3b

ID

ZDB-GENE-050107-1

Name

erb-b2 receptor tyrosine kinase 3b

Symbol

erbb3b Nomenclature History

Previous Names

hps
hypersensitive (1)
pcs
picasso

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including axonal fasciculation; fin regeneration; and gliogenesis. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Is expressed in fin; heart; and nervous system. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 35 figures from 15 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With erbb3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lethal congenital contracture syndrome 2	Alliance	?Lethal congenital contractural syndrome 2	607598
neuronal intestinal dysplasia type A	Alliance	Visceral neuropathy, familial, 1, autosomal recessive	243180
		{?Erythroleukemia, familial, susceptibility to}	133180

Associated With erbb3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000494	Receptor L-domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR006211	Furin-like cysteine-rich domain
Domain	IPR032778	Growth factor receptor domain 4
Family	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036941	Receptor L-domain superfamily
Homologous_superfamily	IPR044912	Epidermal growth factor receptor, juxtamembrane domain
Repeat	IPR006212	Furin-like repeat