ZFIN is now using GRCz12tu for Genomic Data
Gene
erbb3b
- ID
- ZDB-GENE-050107-1
- Name
- erb-b2 receptor tyrosine kinase 3b
- Symbol
- erbb3b Nomenclature History
- Previous Names
-
- hps
- hypersensitive (1)
- pcs
- picasso
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable neuregulin binding activity and neuregulin receptor activity. Acts upstream of or within several processes, including axonal fasciculation; fin regeneration; and gliogenesis. Predicted to be located in endomembrane system and membrane. Predicted to be part of signaling receptor complex. Predicted to be active in basal plasma membrane. Is expressed in fin; heart; integument; and nervous system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lethal congenital contracture syndrome 2 | Alliance | ?Lethal congenital contractural syndrome 2 | 607598 |
| neuronal intestinal dysplasia type A | Alliance | Visceral neuropathy, familial, 1, autosomal recessive | 243180 |
| {?Erythroleukemia, familial, susceptibility to} | 133180 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Family | IPR016245 | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Homologous_superfamily | IPR044912 | Epidermal growth factor receptor, juxtamembrane domain |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Epidermal growth factor receptor, juxtamembrane domain | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5G254 | InterPro | 1429 | |||||||||||||
| UniProtKB:A0A8M2B911 | InterPro | 1427 | |||||||||||||
| UniProtKB:A0A8M9P541 | InterPro | 1426 | |||||||||||||
| UniProtKB:A0A8M1N4R3 | InterPro | 1429 | |||||||||||||
| UniProtKB:A0AC58IJV0 | InterPro | 1000 | |||||||||||||
| UniProtKB:A0AC58IJY8 | InterPro | 998 | |||||||||||||
| UniProtKB:A0AC58IJZ9 | InterPro | 1424 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
erbb3b-201
(1)
|
Ensembl | 4,290 nt | ||
| mRNA |
erbb3b-202
(1)
|
Ensembl | 4,636 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers