ZFIN ID: ZDB-GENE-050107-1
Gene Name: erb-b2 receptor tyrosine kinase 3b
Gene Symbol: erbb3b    Nomenclature History

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Previous Names: hps, hypersensitive (1), pcs, picasso

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have neuregulin binding activity; neuregulin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including axonal fasciculation; fin regeneration; and gliogenesis. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in fin; heart; and nervous system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
Genome Resources: Alliance (1),  Gene:544664 (1),  Ensembl(GRCz11):ENSDARG00000036993 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
erbb3b_unspecified Unspecified Unknown Unknown
hg115 Small Deletion Unknown Unknown CRISPR
sa5978 Point Mutation Unknown Splice Site ENU
sa8650 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14974 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18520 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29934 Point Mutation Unknown Premature Stop ENU
    sa37713 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37714 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st14 Point Mutation Unknown Missense ENU
    st48 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t5419 Unknown Unknown Unknown
    t20458 Point Mutation Unknown Premature Stop
  • European Zebrafish Resource Center (EZRC) (order this)
  • t21411 Unknown Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • t23877 Point Mutation Unknown Premature Stop
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc288d Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • utr2e1 Point Mutation Unknown Premature Stop ENU
    wpr2e2 Point Mutation Unknown Premature Stop ENU
    zf165 Point Mutation Unknown Premature Stop
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-erbb3b N/A 4
    DISEASE ASSOCIATED WITH erbb3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lethal congenital contracture syndrome 2 Alliance ?Lethal congenital contractural syndrome 2 607598
    {?Erythroleukemia, familial, susceptibility to} 133180
    DISEASE ASSOCIATED WITH erbb3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonal fasciculation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein kinase activity (more)
    GO Terms (all 36)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA erbb3b-202 (1)    Ensembl 4636
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM erbb3b No data available
    MARKER RELATIONSHIPS
    erbb3b Contained in: [BAC] DKEY-151G10 (order this)
    erbb3b Contains: [STS] zfish37251-627a06.p1c (1)
    erbb3b Encodes: [EST] fi48d12 (1)
    [cDNA] MGC:193982 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014826 (1) 4644 nt
    Genomic GenBank:CR382340 (1) 158509 nt
    Select Tool
    Polypeptide UniProtKB:B3DH46 (1) 1429 aa
    Sequence Information (all 20)
    ORTHOLOGY for erbb3b ( Chr: 23 )
    CITATIONS (61)