Gene

erbb3b

ID
ZDB-GENE-050107-1
Name
erb-b2 receptor tyrosine kinase 3b
Symbol
erbb3b Nomenclature History
Previous Names
  • hps
  • hypersensitive (1)
  • pcs
  • picasso
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have neuregulin binding activity; neuregulin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including axonal fasciculation; fin regeneration; and gliogenesis. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in fin; heart; and nervous system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With erbb3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lethal congenital contracture syndrome 2 Alliance ?Lethal congenital contractural syndrome 2 607598
{?Erythroleukemia, familial, susceptibility to} 133180
Associated With erbb3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR032778 Growth factor receptor domain 4
Family IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Growth factor receptor domain 4 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine protein kinase, EGF/ERB/XmrK receptor
UniProtKB:A0A2R8QQ09 1417
UniProtKB:E9QC99 1426
UniProtKB:F1QP50 1429
UniProtKB:Q5G254 1429
UniProtKB:B3DH46 1429
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations