Gene
erbb3b
- ID
- ZDB-GENE-050107-1
- Name
- erb-b2 receptor tyrosine kinase 3b
- Symbol
- erbb3b Nomenclature History
- Previous Names
-
- hps
- hypersensitive (1)
- pcs
- picasso
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable neuregulin binding activity; neuregulin receptor activity; and protein kinase activity. Acts upstream of or within several processes, including axonal fasciculation; fin regeneration; and gliogenesis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in fin; heart; integument; and nervous system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| erbb3b_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| hg115 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa5978 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa8650 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14974 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18520 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29934 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37713 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37714 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| st14 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-erbb3b | (2) | |
| CRISPR2-erbb3b | Kang et al., 2024 | |
| MO1-erbb3b | N/A | (4) |
| MO2-erbb3b | N/A | Liu et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lethal congenital contracture syndrome 2 | Alliance | ?Lethal congenital contractural syndrome 2 | 607598 |
| neuronal intestinal dysplasia type A | Alliance | Visceral neuropathy, familial, 1, autosomal recessive | 243180 |
| {?Erythroleukemia, familial, susceptibility to} | 133180 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Family | IPR016245 | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Homologous_superfamily | IPR044912 | Epidermal growth factor receptor, juxtamembrane domain |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Epidermal growth factor receptor, juxtamembrane domain | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5G254 | InterPro | 1429 | |||||||||||||
| UniProtKB:A0A8M2B911 | InterPro | 1427 | |||||||||||||
| UniProtKB:A0A8M9P541 | InterPro | 1426 | |||||||||||||
| UniProtKB:A0A8M1N4R3 | InterPro | 1429 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
erbb3b-201
(1)
|
Ensembl | 4,290 nt | ||
| mRNA |
erbb3b-202
(1)
|
Ensembl | 4,636 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151G10 | ||
| Contains | STS | zfish37251-627a06.p1c | ZFIN Curated Data | |
| Encodes | EST | fi48d12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193982 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001014826 (1) | 4645 nt | ||
| Genomic | GenBank:CU041388 (1) | 205786 nt | ||
| Polypeptide | UniProtKB:A0A8M1N4R3 (1) | 1429 aa |
- Kang, Q., Jia, J., Dean, E.D., Yuan, H., Dai, C., Li, Z., Jiang, F., Zhang, X.K., Powers, A.C., Chen, W., Li, M. (2024) ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia. The Journal of biological chemistry. 300(8):107499
- Liu, K., Chen, R., Zhang, M., Gong, Y., Wang, Y., Cai, W. (2023) ERBB3 deficiency causes a multisystemic syndrome in human patient and zebrafish. Clinical genetics. 105(3):283-293
- Bump, R.G., Goo, C.E.A., Horton, E.C., Rasmussen, J.P. (2022) Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis. Development (Cambridge, England). 149(3):
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Lysko, D.E., Talbot, W.S. (2022) Unmyelinated sensory neurons use Neuregulin signals to promote myelination of interneurons in the CNS. Cell Reports. 41:111669
- Zhang, L., Wan, M., Tohti, R., Jin, D., Zhong, T.P. (2022) Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation. International Journal of Molecular Sciences. 23(22):
- Brown, E.A., Kawakami, K., Kucenas, S. (2021) A novel gene trap line for visualization and manipulation of erbb3b+ neural crest and glial cells in zebrafish. Developmental Biology. 482:114-123
- Fontenas, L., Kucenas, S. (2021) Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia. eLIFE. 10:
- Laplace-Builhé, B., Barthelaix, A., Assou, S., Bohaud, C., Pratlong, M., Severac, D., Tejedor, G., Luz-Crawford, P., Nguyen-Chi, M., Mathieu, M., Jorgensen, C., Djouad, F. (2021) NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration. Nature communications. 12:6336
- Ka, J., Kim, J.D., Pak, B., Han, O., Choi, W., Kim, H., Jin, S.W. (2020) Bone Morphogenetic Protein Signaling Restricts Proximodistal Extension of the Ventral Fin Fold. Frontiers in cell and developmental biology. 8:603306
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