Gene

tfr2

ID

ZDB-GENE-041220-3

Name

transferrin receptor 2

Symbol

tfr2 Nomenclature History

Previous Names

zgc:123043

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have transferrin receptor activity. Involved in iron ion homeostasis. Predicted to localize to integral component of membrane. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Is expressed in liver. Orthologous to human TFR2 (transferrin receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Basu et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfr2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hemochromatosis type 3	Alliance	Hemochromatosis, type 3	604250

Associated With tfr2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
hemochromatosis type 3	tfr2^f6/f6	standard conditions	Basu et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003137	PA domain
Domain	IPR007484	Peptidase M28
Domain	IPR037324	Transferrin receptor protein 1/2, PA domain
Family	IPR039373	Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Homologous_superfamily	IPR036757	Transferrin receptor-like, dimerisation domain superfamily
Homologous_superfamily	IPR046450	PA domain superfamily

Domain Details Per Protein

Protein	Length	PA domain	PA domain superfamily	Peptidase M28	Transferrin receptor-like, dimerisation domain superfamily	Transferrin receptor protein 1/2, PA domain	Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
UniProtKB:A0A0G2KE94 InterPro	778
UniProtKB:Q5MPX2 InterPro	783

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tfr2-201 (1) Ensembl	Ensembl		2,352 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tfr2	polyclonal	tfr2		Rabbit	WB	AnaSpec	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations