Gene

unc5b

ID
ZDB-GENE-041213-1
Name
unc-5 netrin receptor B
Symbol
unc5b Nomenclature History
Previous Names
  • sb:eu495
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have netrin receptor activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of angiogenesis. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; pectoral fin bud; and trunk vasculature. Orthologous to human UNC5B (unc-5 netrin receptor B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With unc5b Human Ortholog
No data available
Associated With unc5b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR000906 ZU5 domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR033772 UPA domain
Domain IPR042156 UNC5B, death domain
Family IPR037936 Netrin receptor UNC5
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Netrin receptor UNC5 Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily UNC5B, death domain UPA domain ZU5 domain
UniProtKB:B3DJI6 940
UniProtKB:F1Q711 911
UniProtKB:A4JYH4 376
UniProtKB:Q5XKY3 452
UniProtKB:A0A0R4IE04 940
UniProtKB:A9JR35 940
UniProtKB:F1QXJ7 929
UniProtKB:B3DJL0 940
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-unc5b monoclonal IgG1 , k Mouse
1
Ab2-unc5b monoclonal IgG1 , k Mouse
  • IHC
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations