Gene
rab25a
- ID
- ZDB-GENE-041212-69
- Name
- RAB25, member RAS oncogene family a
- Symbol
- rab25a Nomenclature History
- Previous Names
-
- rab25
- si:dkeyp-84f11.7
- zgc:101648
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cortical actin cytoskeleton organization; regulation of cytokinesis; and regulation of endocytic recycling. Predicted to be active in Golgi apparatus and recycling endosome. Is expressed in EVL. Orthologous to human RAB25 (RAB25, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Willoughby et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rab25a | (2) | |
| MO1-rab25a | N/A | Melvin et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Rab GTPases family involved in membrane trafficking | Small GTPase | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LVA5 | InterPro | 210 | ||||
| UniProtKB:A0AB32T9L6 | InterPro | 186 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rab25a-201
(1)
|
Ensembl | 1,822 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-312O15 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-84F11 | ||
| Encodes | EST | eu545 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:101648 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193014 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001008641 (1) | 2154 nt | ||
| Genomic | GenBank:BX890617 (1) | 182182 nt | ||
| Polypeptide | UniProtKB:Q1LVA5 (1) | 210 aa |
- Willoughby, P.M., Allen, M., Yu, J., Korytnikov, R., Chen, T., Liu, Y., So, I., Macpherson, N., Mitchell, J.A., Fernandez-Gonzalez, R., Bruce, A.E.E. (2021) The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium. eLIFE. 10:
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hall, T.E., Martel, N., Lo, H.P., Xiong, Z., Parton, R.G. (2017) A plasmid library of full-length zebrafish rab proteins for in vivo cell biology.. Cellular logistics. 7:e1301151
- Wei, S., Dai, M., Liu, Z., Ma, Y., Shang, H., Cao, Y., Wang, Q. (2017) The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Cell Research. 27(2):202-225
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Melvin, V.S., Feng, W., Hernandez-Lagunas, L., Artinger, K.B., and Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(7):817-31
- Piloto, S., and Schilling, T.F. (2010) Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration. Development (Cambridge, England). 137(12):1981-1990
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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