Gene
oclnb
- ID
- ZDB-GENE-041212-43
- Name
- occludin b
- Symbol
- oclnb Nomenclature History
- Previous Names
-
- wu:fk83f10
- zgc:101820
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Is expressed in several structures, including EVL; digestive system; extension; pleuroperitoneal region; and sensory system. Orthologous to human OCLN (occludin).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 17 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101820 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
pseudo-TORCH syndrome 1 | Alliance | Pseudo-TORCH syndrome 1 | 251290 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | ELL/occludin family | Marvel domain | Occludin homology domain |
---|---|---|---|---|
UniProtKB:Q5PRA1
|
461 | |||
UniProtKB:A2BGQ3
|
471 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-214J8 | ZFIN Curated Data | |
Encodes | EST | fk83f10 | ZFIN Curated Data | |
Encodes | cDNA | MGC:101820 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191857 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001008618 (1) | 2195 nt | ||
Genomic | GenBank:BX510923 (1) | 165838 nt | ||
Polypeptide | UniProtKB:A2BGQ3 (1) | 471 aa |
- Song, Y., Fan, S., Zhang, D., Li, J., Li, Z., Li, Z., Xiao, W., Wang, J. (2023) Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. Journal of virology. 97(2):e0133822
- Luo, T., Wang, X., Jin, Y. (2021) Low concentrations of imidacloprid exposure induced gut toxicity in adult zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 241:108972
- Chen, Z., Zhijie, C., Yuting, Z., Shilin, X., Qichun, Z., Jinying, O., Chaohua, L., Jing, L., Zhixian, M. (2020) Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Frontiers in microbiology. 11:946
- Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330
- van den Bos, R., Cromwijk, S., Tschigg, K., Althuizen, J., Zethof, J., Whelan, R., Flik, G., Schaaf, M. (2020) Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. Frontiers in immunology. 11:727
- Cokus, S.J., De La Torre, M., Medina, E.F., Rasmussen, J.P., Ramirez-Gutierrez, J., Sagasti, A., Wang, F. (2019) Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos. G3 (Bethesda). 9(10):3439-3452
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
- Mathiyalagan, N., Miles, L.B., Anderson, P.J., Wilanowski, T., Grills, B.L., McDonald, S.J., Keightley, M.C., Charzynska, A., Dabrowski, M., Dworkin, S. (2019) Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Genes. 10(11)
- Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274
- Guo, X., Li, J., Ran, C., Wang, A., Xie, M., Xie, Y., Ding, Q., Zhang, Z., Yang, Y., Zhou, Z. (2018) Dietary nucleotides can directly stimulate the immunity of zebrafish independent of the intestinal microbiota. Fish & shellfish immunology. 86:1064-1071
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