Gene
dclre1c
- ID
- ZDB-GENE-041210-72
- Name
- DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
- Symbol
- dclre1c Nomenclature History
- Previous Names
-
- im:7141637
- si:dkey-153k10.3
- zgc:136877
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 5'-3' exodeoxyribonuclease activity and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; interstrand cross-link repair; and protection from non-homologous end joining at telomere. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be part of nonhomologous end joining complex. Human ortholog(s) of this gene implicated in Omenn syndrome; common variable immunodeficiency; severe combined immunodeficiency; and severe combined immunodeficiency with sensitivity to ionizing radiation. Orthologous to human DCLRE1C (DNA cross-link repair 1C).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141637 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Omenn syndrome | Alliance | Omenn syndrome | 603554 |
severe combined immunodeficiency with sensitivity to ionizing radiation | Alliance | Severe combined immunodeficiency, Athabascan type | 602450 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | DNA repair metallo-beta-lactamase | Metallo-beta-lactamase | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
---|---|---|---|---|
UniProtKB:A0A8M9Q5Y8
|
639 | |||
UniProtKB:Q5RGE5
|
639 | |||
UniProtKB:A0A8M9Q5Y6
|
680 | |||
UniProtKB:A0A8M9PHC7
|
379 | |||
UniProtKB:A0A8M6YZK4
|
663 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
dclre1c-201
(1)
|
Ensembl | 2,400 nt | ||
mRNA |
dclre1c-203
(1)
|
Ensembl | 689 nt | ||
ncRNA |
dclre1c-002
(1)
|
Ensembl | 880 nt |
Interactions and Pathways
No data available
Plasmids
No data available