Gene
dclre1c
- ID
- ZDB-GENE-041210-72
- Name
- DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
- Symbol
- dclre1c Nomenclature History
- Previous Names
-
- im:7141637
- si:dkey-153k10.3
- zgc:136877
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 5'-3' DNA exonuclease activity and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; interstrand cross-link repair; and telomere maintenance. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be part of nonhomologous end joining complex. Human ortholog(s) of this gene implicated in Omenn syndrome; common variable immunodeficiency; severe combined immunodeficiency; and severe combined immunodeficiency with sensitivity to ionizing radiation. Orthologous to human DCLRE1C (DNA cross-link repair 1C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141637 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015534Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024761Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029043Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Omenn syndrome | Alliance | Omenn syndrome | 603554 |
| severe combined immunodeficiency with sensitivity to ionizing radiation | Alliance | Severe combined immunodeficiency, Athabascan type | 602450 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair metallo-beta-lactamase | Metallo-beta-lactamase | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q5Y8 | InterPro | 639 | |||
| UniProtKB:Q5RGE5 | InterPro | 639 | |||
| UniProtKB:A0A8M9Q5Y6 | InterPro | 680 | |||
| UniProtKB:A0A8M9PHC7 | InterPro | 379 | |||
| UniProtKB:A0A8M6YZK4 | InterPro | 663 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dclre1c-201
(1)
|
Ensembl | 2,400 nt | ||
| mRNA |
dclre1c-203
(1)
|
Ensembl | 689 nt | ||
| ncRNA |
dclre1c-002
(1)
|
Ensembl | 880 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-153K10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7141637 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136877 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045101 (1) | 2400 nt | ||
| Genomic | GenBank:BX901962 (1) | 182550 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q5Y6 (1) | 680 aa |
- Thyme, S.B., Schier, A.F. (2016) Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development. Cell Reports. 15(4):707-714
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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