Gene
adipor2
- ID
- ZDB-GENE-041210-60
- Name
- adiponectin receptor 2
- Symbol
- adipor2 Nomenclature History
- Previous Names
-
- si:ch211-281k12.9
- zgc:136273
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Predicted to be involved in adiponectin-activated signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including ball; brain; fat cell; head; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus. Orthologous to human ADIPOR2 (adiponectin receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| vu502Gt | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004254 | AdipoR/Haemolysin-III-related |
Domain Details Per Protein
| Protein | Additional Resources | Length | AdipoR/Haemolysin-III-related |
|---|---|---|---|
| UniProtKB:Q5TYU5 | InterPro | 358 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adipor2-201
(1)
|
Ensembl | 2,500 nt | ||
| mRNA |
adipor2-202
(1)
|
Ensembl | 5,983 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-211C7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-281K12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136273 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174249 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174250 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192028 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025506 (1) | 1762 nt | ||
| Genomic | GenBank:CT027540 (1) | 238518 nt | ||
| Polypeptide | UniProtKB:Q5TYU5 (1) | 358 aa |
- Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):
- Zhou, Y., Guo, W., Lei, L., Sun, Y., Li, R., Guo, Y., Yang, L., Shi, X., Han, J., Zhou, B. (2021) Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition. Environmental pollution (Barking, Essex : 1987). 290:118127
- Yu, L., Gong, L., Wang, C., Hu, N., Tang, Y., Zheng, L., Dai, X., Li, Y. (2020) Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway. Drug design, development and therapy. 14:1493-1506
- Collins, M.M., Ahlberg, G., Hansen, C.V., Guenther, S., Marín-Juez, R., Sokol, A.M., El-Sammak, H., Piesker, J., Hellsten, Y., Olesen, M.S., Stainier, D.Y.R., Lundegaard, P.R. (2019) Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proceedings of the National Academy of Sciences of the United States of America. 116(48):24115-24121
- Rastegar, S., Parimisetty, A., Cassam-Sulliman, N., Narra Sai, S., Weber, S., Rastegar, M., Viranaicken, W., Couret, D., Planesse, C., Strähle, U., Meilhac, O., Lefebvre d'Hellencourt, C., Diotel, N. (2019) Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair. The Journal of comparative neurology. 527(14):2317-2333
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Wu, C., Gao, J., Chen, L., Shao, X., Ye, J. (2018) Identification, characterization, and expression analysis of adiponectin receptors in black carp Mylopharyngodon piceus in response to dietary carbohydrate. Fish physiology and biochemistry. 44(4):1127-1141
- Schneider, A.C., Gregório, C., Uribe-Cruz, C., Guizzo, R., Malysz, T., Faccioni-Heuser, M.C., Longo, L., da Silveira, T.R. (2017) Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver. World journal of hepatology. 9:418-426
- Schüttler, A., Reiche, K., Altenburger, R., Busch, W. (2017) The transcriptome of the zebrafish embryo after chemical exposure - a meta-analysis. Toxicological sciences : an official journal of the Society of Toxicology. 157(2):291-304
- Guillot, R., Cortés, R., Navarro, S., Mischitelli, M., García-Herranz, V., Sánchez, E., Cal, L., Navarro, J.C., Míguez, J., Afanasyev, S., Krasnov, A., Cone, R.D., Rotllant, J., Cerdá-Reverter, J.M. (2016) Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach. Hormones and behavior. 82:87-100
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