Gene

ppat

ID

ZDB-GENE-041210-323

Name

phosphoribosyl pyrophosphate amidotransferase

Symbol

ppat Nomenclature History

Previous Names

im:6894693
si:dkeyp-117h8.5
wu:fb61f03
wu:fc28b09

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable amidophosphoribosyltransferase activity. Predicted to be involved in purine nucleotide biosynthetic process. Predicted to act upstream of or within glutamine metabolic process and purine nucleobase biosynthetic process. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pectoral fin bud; and segmental plate. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6894693 (11 images)
IMAGE:7152599 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppat Human Ortholog

No data available

Associated With ppat Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000836	Phosphoribosyltransferase domain
Domain	IPR017932	Glutamine amidotransferase type 2 domain
Domain	IPR035584	Amidophosphoribosyltransferase, N-terminal
Family	IPR005854	Amidophosphoribosyltransferase
Homologous_superfamily	IPR029055	Nucleophile aminohydrolases, N-terminal
Homologous_superfamily	IPR029057	Phosphoribosyltransferase-like

Domain Details Per Protein

Protein	Additional Resources	Length	Amidophosphoribosyltransferase	Amidophosphoribosyltransferase, N-terminal	Glutamine amidotransferase type 2 domain	Nucleophile aminohydrolases, N-terminal	Phosphoribosyltransferase domain	Phosphoribosyltransferase-like
UniProtKB:A6H8S4	InterPro	508

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ppat-201 (1) Ensembl	Ensembl		2,680 nt	Select Tool ZFIN BLAST
mRNA	ppat-202 (1) Ensembl	Ensembl		663 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations