Gene
ela2
- ID
- ZDB-GENE-041117-1
- Name
- elastase 2
- Symbol
- ela2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in adipose tissue; intestine; and liver.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa31650 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR050850 | Peptidase S1 family, Elastase subfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Peptidase S1A, chymotrypsin family | Peptidase S1 family, Elastase subfamily | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q5I4 | InterPro | 266 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24F17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-163F12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001139464 (1) | 891 nt | ||
| Genomic | GenBank:BX784023 (1) | 231254 nt | ||
| Polypeptide | UniProtKB:F1Q5I4 (1) | 266 aa |
No data available
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
- Xiong, G., Deng, Y., Li, J., Cao, Z., Liao, X., Liu, Y., Lu, H. (2019) Immunotoxicity and transcriptome analysis of zebrafish embryos in response to glufosinate-ammonium exposure. Chemosphere. 236:124423
- Wei, Y., Huang, L., Cao, J., Wang, C., Yan, J. (2018) Dietary Safety Assessment of Flk1-Transgenic Fish. Frontiers in Physiology. 9:8
- Mesquita, S.R., van Drooge, B.L., Dall'Osto, M., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piña, B. (2017) Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona). Environmental science and pollution research international. 24(18):15406-15415
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z. (2017) LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 44(6):307-317
- Mesquita, S.R., Dachs, J., van Drooge, B.L., Castro-Jiménez, J., Navarro-Martín, L., Barata, C., Vieira, N., Guimarães, L., Piña, B. (2016) Toxicity assessment of atmospheric particulate matter in the Mediterranean and Black Seas open waters. The Science of the total environment. 545-546:163-170
- Mesquita, S.R., van Drooge, B.L., Oliveira, E., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piña, B. (2015) Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environmental pollution (Barking, Essex : 1987). 206:535-542
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