Gene
nexn
- ID
- ZDB-GENE-041114-92
- Name
- nexilin (F actin binding protein)
- Symbol
- nexn Nomenclature History
- Previous Names
-
- zgc:103442 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have cell-cell adhesion mediator activity. Involved in cardiac muscle fiber development. Localizes to Z disc. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Is expressed in adaxial cell; cardiovascular system; musculature system; and somite. Orthologous to human NEXN (nexilin F-actin binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103442 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hassel et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1CC | Alliance | Cardiomyopathy, dilated, 1CC | 613122 |
| hypertrophic cardiomyopathy 20 | Alliance | Cardiomyopathy, hypertrophic, 20 | 613876 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold |
|---|---|---|---|---|---|---|
|
UniProtKB:A2BEV6
|
861 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
al844185.1-201
(1)
|
Ensembl | 907 nt | ||
| mRNA |
nexn-201
(1)
|
Ensembl | 2,442 nt | ||
| mRNA |
nexn-202
(1)
|
Ensembl | 3,338 nt | ||
| mRNA |
nexn-204
(1)
|
Ensembl | 785 nt | ||
| mRNA |
nexn-206
(1)
|
Ensembl | 987 nt | ||
| mRNA |
nexn-208
(1)
|
Ensembl | 4,774 nt | ||
| mRNA |
nexn-209
(1)
|
Ensembl | 4,726 nt | ||
| ncRNA |
nexn-002
(1)
|
Ensembl | 653 nt | ||
| ncRNA |
nexn-005
(1)
|
Ensembl | 819 nt | ||
| ncRNA |
nexn-006
(1)
|
Ensembl | 361 nt |
Interactions and Pathways
No data available
Plasmids
No data available