Gene

nexn

ID

ZDB-GENE-041114-92

Name

nexilin (F actin binding protein)

Symbol

nexn Nomenclature History

Previous Names

zgc:103442 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have cell-cell adhesion mediator activity. Involved in cardiac muscle fiber development. Localizes to Z disc. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Is expressed in adaxial cell; cardiovascular system; musculature system; and somite. Orthologous to human NEXN (nexilin F-actin binding protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103442 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hassel et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nexn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1CC	Alliance	Cardiomyopathy, dilated, 1CC	613122
hypertrophic cardiomyopathy 20	Alliance	Cardiomyopathy, hypertrophic, 20	613876

Associated With nexn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold
UniProtKB:A2BEV6 InterPro	861

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	al844185.1-201 (1) Ensembl	Ensembl	907 nt	Select Tool
mRNA	nexn-201 (1) Ensembl	Ensembl	2,442 nt	Select Tool ZFIN BLAST
mRNA	nexn-202 (1) Ensembl	Ensembl	3,338 nt	Select Tool
mRNA	nexn-204 (1) Ensembl	Ensembl	785 nt	Select Tool
mRNA	nexn-206 (1) Ensembl	Ensembl	987 nt	Select Tool
mRNA	nexn-208 (1) Ensembl	Ensembl	4,774 nt	Select Tool ZFIN BLAST
mRNA	nexn-209 (1) Ensembl	Ensembl	4,726 nt	Select Tool ZFIN BLAST
ncRNA	nexn-002 (1) Ensembl	Ensembl	653 nt	Select Tool
ncRNA	nexn-005 (1) Ensembl	Ensembl	819 nt	Select Tool
ncRNA	nexn-006 (1) Ensembl	Ensembl	361 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations