Gene

mvk

ID
ZDB-GENE-041114-37
Name
mevalonate kinase
Symbol
mvk Nomenclature History
Previous Names
  • zgc:103473
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable mevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to act upstream of or within isoprenoid biosynthetic process; phosphorylation; and sterol metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in liver. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mvk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mevalonic aciduria Alliance Mevalonic aciduria 610377
Hyper-IgD syndrome 260920
Porokeratosis 3, multiple types 175900
Associated With mvk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR006203 GHMP kinase, ATP-binding, conserved site
Domain IPR006204 GHMP kinase N-terminal domain
Domain IPR013750 GHMP kinase, C-terminal domain
Family IPR006205 Mevalonate kinase
Homologous_superfamily IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Homologous_superfamily IPR020568 Ribosomal protein S5 domain 2-type fold
Homologous_superfamily IPR036554 GHMP kinase, C-terminal domain superfamily
Domain Details Per Protein
Protein Length GHMP kinase, ATP-binding, conserved site GHMP kinase, C-terminal domain GHMP kinase, C-terminal domain superfamily GHMP kinase N-terminal domain Mevalonate kinase Ribosomal protein S5 domain 2-type fold Ribosomal protein S5 domain 2-type fold, subgroup
UniProtKB:Q5U3I7 396
UniProtKB:A2BGN1 396
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations