kmt5b

ID

ZDB-GENE-041114-22

Name

lysine methyltransferase 5B

Symbol

kmt5b Nomenclature History

Previous Names

suv420h1 (1)
wu:fb97g06
wu:fi57g03
zgc:103527

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables histone H4K20 methyltransferase activity. Acts upstream of or within regulation of growth. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Orthologous to human KMT5B (lysine methyltransferase 5B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103527 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kmt5b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 51	Alliance	Intellectual developmental disorder, autosomal dominant 51	617788

Associated With kmt5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001214	SET domain
Domain	IPR044424	KMT5B , SET domain
Family	IPR025790	Suv4-20 family, animal
Family	IPR039977	Histone-lysine N-methyltransferase Suv4-20/Set9
Homologous_superfamily	IPR041938	Histone-lysine N-methyltransferase, N-terminal domain
Homologous_superfamily	IPR046341	SET domain superfamily