Gene

ddx11

ID
ZDB-GENE-041114-191
Name
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Symbol
ddx11 Nomenclature History
Previous Names
  • fa08b08
  • wu:fa08b08
  • zgc:92172 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have DNA helicase activity. Involved in nucleolar chromatin organization; rRNA transcription; and regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to localize to nucleus. Used to study Warsaw breakage syndrome. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Sun et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ddx11 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Warsaw breakage syndrome Alliance Warsaw breakage syndrome 613398
Associated With ddx11 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006554 Helicase-like, DEXD box c2 type
Domain IPR006555 ATP-dependent helicase, C-terminal
Domain IPR010614 DEAD2
Domain IPR014013 Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
Family IPR013020 ATP-dependent helicase Rad3/Chl1-like
Family IPR028331 ATP-dependent RNA helicase CHL1/DDX11
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length ATP-dependent helicase, C-terminal ATP-dependent helicase Rad3/Chl1-like ATP-dependent RNA helicase CHL1/DDX11 DEAD2 Helicase-like, DEXD box c2 type Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1R345 890
UniProtKB:A0A2R8QL47 861
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations