Gene
ddx11
- ID
- ZDB-GENE-041114-191
- Name
- DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
- Symbol
- ddx11 Nomenclature History
- Previous Names
-
- fa08b08
- wu:fa08b08
- zgc:92172 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA helicase activity. Acts upstream of or within nucleolar chromatin organization; rRNA transcription; and regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nucleolus. Predicted to be active in nucleus. Used to study Warsaw breakage syndrome. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92172 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sun et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Warsaw breakage syndrome | Alliance | Warsaw breakage syndrome | 613398 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Warsaw breakage syndrome | WT + MO2-ddx11 | standard conditions | Sun et al., 2015 |
| Warsaw breakage syndrome | WT + MO1-ddx11 | standard conditions | Sun et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006554 | Helicase-like, DEXD box c2 type |
| Domain | IPR006555 | ATP-dependent helicase, C-terminal |
| Domain | IPR010614 | RAD3-like helicase, DEAD |
| Domain | IPR014013 | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type |
| Family | IPR013020 | ATP-dependent helicase Rad3/Chl1-like |
| Family | IPR045028 | Helicase superfamily 1/2, DinG/Rad3-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | ATP-dependent helicase, C-terminal | ATP-dependent helicase Rad3/Chl1-like | Helicase-like, DEXD box c2 type | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | Helicase superfamily 1/2, DinG/Rad3-like | P-loop containing nucleoside triphosphate hydrolase | RAD3-like helicase, DEAD |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R345
|
890 |
Interactions and Pathways
No data available
Plasmids
No data available