Gene
fbxl4
- ID
- ZDB-GENE-041114-187
- Name
- F-box and leucine-rich repeat protein 4
- Symbol
- fbxl4 Nomenclature History
- Previous Names
-
- zgc:92297
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to localize to SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92297 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Lavorato et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
mitochondrial DNA depletion syndrome 13 | Alliance | Mitochondrial DNA depletion syndrome 13 (encephalomyopathic type) | 615471 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
mitochondrial DNA depletion syndrome 13 | fbxl4sa12470/sa12470 | standard conditions | Lavorato et al., 2022 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | F-box domain | F-box-like domain superfamily | Leucine-rich repeat, cysteine-containing subtype | Leucine-rich repeat domain superfamily |
---|---|---|---|---|---|
UniProtKB:Q5U388
|
607 |
Interactions and Pathways
No data available
Plasmids
No data available