Gene

ppm1bb

ID

ZDB-GENE-041114-185

Name

protein phosphatase, Mg2+/Mn2+ dependent, 1Bb

Symbol

ppm1bb Nomenclature History

Previous Names

ppm1a
fc18g04
wu:fc18g04
zgc:92329

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have magnesium-dependent protein serine/threonine phosphatase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to localize to cytosol and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Lin et al., 2006

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppm1bb Human Ortholog

No data available

Associated With ppm1bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000222	PPM-type phosphatase, divalent cation binding
Domain	IPR001932	PPM-type phosphatase-like domain
Domain	IPR012911	Protein serine/threonine phosphatase 2C, C-terminal
Family	IPR015655	Protein phosphatase 2C
Homologous_superfamily	IPR036457	PPM-type phosphatase-like domain superfamily
Homologous_superfamily	IPR036580	Phosphatase 2C, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Phosphatase 2C, C-terminal domain superfamily	PPM-type phosphatase, divalent cation binding	PPM-type phosphatase-like domain	PPM-type phosphatase-like domain superfamily	Protein phosphatase 2C	Protein serine/threonine phosphatase 2C, C-terminal
UniProtKB:A0A8M2B2A8 InterPro	475
UniProtKB:Q5U386 InterPro	382

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ppm1bb-201 (1) Ensembl	Ensembl	3,617 nt	Select Tool ZFIN BLAST
mRNA	ppm1bb-204 (1) Ensembl	Ensembl	5,124 nt	Select Tool ZFIN BLAST
ncRNA	ppm1bb-002 (1) Ensembl	Ensembl	1,771 nt	Select Tool ZFIN BLAST
ncRNA	ppm1bb-003 (1) Ensembl	Ensembl	877 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations