Gene
neil3
- ID
- ZDB-GENE-041114-18
- Name
- nei-like DNA glycosylase 3
- Symbol
- neil3 Nomenclature History
- Previous Names
-
- zgc:103553 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA N-glycosylase activity and DNA-(apurinic or apyrimidinic site) endonuclease activity. Predicted to be involved in base-excision repair. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Orthologous to human NEIL3 (nei like DNA glycosylase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908987 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35732 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR015887 | DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site |
| Domain | IPR000214 | Zinc finger, DNA glycosylase/AP lyase-type |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Domain | IPR010666 | Zinc finger, GRF-type |
| Domain | IPR012319 | Formamidopyrimidine-DNA glycosylase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA glycosylase/AP lyase, H2TH DNA-binding | DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site | Formamidopyrimidine-DNA glycosylase, catalytic domain | MutM-like, N-terminal | Small ribosomal subunit protein uS13-like, H2TH | Zinc finger, DNA glycosylase/AP lyase-type | Zinc finger, GRF-type | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5U3G8 | InterPro | 550 | |||||||||
| UniProtKB:F1Q570 | InterPro | 568 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-115G4 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6908987 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:103553 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174323 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191446 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007335 (1) | 1920 nt | ||
| Genomic | GenBank:CR759803 (1) | 171491 nt | ||
| Polypeptide | UniProtKB:F1Q570 (1) | 568 aa |
- Torisu, K., Tsuchimoto, D., Ohnishi, Y., and Nakabeppu, Y. (2005) Hematopoietic Tissue-Specific Expression of Mouse Neil3 for Endonuclease VIII-Like Protein. J. Biochem. (Tokyo). 138(6):763-772
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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