Gene
cyp1d1
- ID
- ZDB-GENE-041114-179
- Name
- cytochrome P450, family 1, subfamily D, polypeptide 1
- Symbol
- cyp1d1 Nomenclature History
- Previous Names
-
- CYP1D1 (1)
- zgc:92205
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables testosterone 6-beta-hydroxylase activity. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including cardiovascular system; digestive system; hypochord; kidney; and nervous system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92205 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP1 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5U396 | InterPro | 512 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp1d1-201
(1)
|
Ensembl | 2,326 nt | ||
| mRNA |
cyp1d1-202
(1)
|
Ensembl | 5,844 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-229D2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92205 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007310 (1) | 2279 nt | ||
| Genomic | GenBank:BX296526 (1) | 179086 nt | ||
| Polypeptide | UniProtKB:Q5U396 (1) | 512 aa |
No data available
- Zhao, X., Huang, X., Peng, W., Han, M., Zhang, X., Zhu, K., Shao, B. (2022) Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish. Ecotoxicology and environmental safety. 238:113568
- Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
- Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356
- Jia, Z.Q., Liu, D., Sheng, C.W., Casida, J.E., Wang, C., Song, P.P., Chen, Y.M., Han, Z.J., Zhao, C.Q. (2018) Acute toxicity, bioconcentration, elimination and antioxidant effects of fluralaner in zebrafish, Danio rerio. Environmental pollution (Barking, Essex : 1987). 232:183-190
- Carmona-Antoñanzas, G., Santi, M., Migaud, H., Vera, L.M. (2017) Light- and clock-control of genes involved in detoxification. Chronobiology International. 34(8):1026-1041
- Puthumana, J., Kim, B.M., Jeong, C.B., Kim, D.H., Kang, H.M., Jung, J.H., Kim, I.C., Hwang, U.K., Lee, J.S. (2017) Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP. Aquatic toxicology (Amsterdam, Netherlands). 187:132-140
- Verbueken, E., Alsop, D., Saad, M.A., Pype, C., Van Peer, E.M., Casteleyn, C.R., Van Ginneken, C.J., Wilson, J., Van Cruchten, S.J. (2017) In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development. International Journal of Molecular Sciences. 18(1)
- Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J. (2017) Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environmental toxicology and chemistry. 36(8):2139-2146
- Yang, Y., Ye, X., He, B., Liu, J. (2016) Cadmium potentiates toxicity of cypermethrin in zebrafish. Environmental toxicology and chemistry. 35(2):435-45
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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