Gene
mllt10
- ID
- ZDB-GENE-041114-176
- Name
- MLLT10 histone lysine methyltransferase DOT1L cofactor
- Symbol
- mllt10 Nomenclature History
- Previous Names
-
- id:ibd5120
- wu:fe48f12
- zgc:92208 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable histone binding activity and nucleosome binding activity. Acts upstream of or within canonical Wnt signaling pathway and intestinal epithelial structure maintenance. Predicted to be active in nucleus. Is expressed in brain; hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92208 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Mahmoudi et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid | 601626 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR034732 | Extended PHD (ePHD) domain |
| Domain | IPR049773 | AF10-like, coiled-coil domain |
| Domain | IPR049775 | AF-10, extended PHD finger |
| Domain | IPR049781 | AF-10/AF-17, PHD finger |
| Family | IPR050701 | Histone Modification Regulator |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Length | AF-10/AF-17, PHD finger | AF-10, extended PHD finger | AF10-like, coiled-coil domain | Extended PHD (ePHD) domain | Histone Modification Regulator | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W451
|
1133 | ||||||||||
|
UniProtKB:A0A8M6YVP0
|
1162 | ||||||||||
|
UniProtKB:A0A8M3AZ26
|
1090 | ||||||||||
|
UniProtKB:A0A8M6Z452
|
1161 | ||||||||||
|
UniProtKB:A0A8M6Z457
|
951 | ||||||||||
|
UniProtKB:A0A8M6YVP4
|
1100 | ||||||||||
|
UniProtKB:A0A8M6YWB4
|
916 | ||||||||||
|
UniProtKB:A0A8M6Z4S2
|
1132 | ||||||||||
|
UniProtKB:A0A8M3AP65
|
1120 | ||||||||||
|
UniProtKB:A0A8M9PUD9
|
1131 | ||||||||||
|
UniProtKB:A0A8M6YY56
|
1154 | ||||||||||
|
UniProtKB:A0A8M6YWA9
|
1158 | ||||||||||
|
UniProtKB:A0A8M6YY61
|
908 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mllt10-201
(1)
|
Ensembl | 2,829 nt | ||
| mRNA |
mllt10-202
(1)
|
Ensembl | 3,069 nt | ||
| mRNA |
mllt10-204
(1)
|
Ensembl | 4,589 nt | ||
| mRNA |
mllt10-206
(1)
|
Ensembl | 6,768 nt | ||
| mRNA |
mllt10-208
(1)
|
Ensembl | 5,383 nt | ||
| mRNA |
mllt10-212
(1)
|
Ensembl | 3,270 nt | ||
| mRNA |
mllt10-213
(1)
|
Ensembl | 3,156 nt | ||
| mRNA |
mllt10-214
(1)
|
Ensembl | 3,180 nt | ||
| ncRNA |
mllt10-004
(1)
|
Ensembl | 834 nt | ||
| ncRNA |
mllt10-005
(1)
|
Ensembl | 840 nt | ||
| ncRNA |
mllt10-006
(1)
|
Ensembl | 784 nt | ||
| ncRNA |
mllt10-007
(1)
|
Ensembl | 714 nt | ||
| ncRNA |
mllt10-008
(1)
|
Ensembl | 711 nt | ||
| ncRNA |
mllt10-009
(1)
|
Ensembl | 849 nt |
Interactions and Pathways
No data available
Plasmids
No data available