Gene

cln3

ID
ZDB-GENE-041114-174
Name
CLN3 lysosomal/endosomal transmembrane protein, battenin
Symbol
cln3 Nomenclature History
Previous Names
  • zgc:92244 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Involved in axonogenesis; lysosome organization; and negative regulation of neuron apoptotic process. Predicted to localize to lysosome. Is expressed in brain; central nervous system; cerebellum; and midbrain hindbrain boundary. Used to study neuronal ceroid lipofuscinosis 3. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from Wager et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cln3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neuronal ceroid lipofuscinosis 3 Alliance Ceroid lipofuscinosis, neuronal, 3 204200
Associated With cln3 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR003492 Batten's disease protein Cln3
Family IPR018460 Batten's disease protein Cln3, subgroup
Homologous_superfamily IPR036259 MFS transporter superfamily
Domain Details Per Protein
Protein Length Batten's disease protein Cln3 Batten's disease protein Cln3, subgroup MFS transporter superfamily
UniProtKB:Q5U392 446
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations