Gene
cln3
- ID
- ZDB-GENE-041114-174
- Name
- CLN3 lysosomal/endosomal transmembrane protein, battenin
- Symbol
- cln3 Nomenclature History
- Previous Names
-
- zgc:92244 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Acts upstream of or within axonogenesis; lysosome organization; and negative regulation of neuron apoptotic process. Predicted to be located in lysosomal membrane. Predicted to be active in lysosome. Is expressed in brain; central nervous system; cerebellum; and midbrain hindbrain boundary. Used to study neuronal ceroid lipofuscinosis 3. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92244 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Wager et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neuronal ceroid lipofuscinosis 3 | Alliance | Ceroid lipofuscinosis, neuronal, 3 | 204200 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| neuronal ceroid lipofuscinosis 3 | TL + MO1-cln3 | standard conditions | Wager et al., 2016 |
| neuronal ceroid lipofuscinosis 3 | TL + MO2-cln3 | standard conditions | Wager et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Batten's disease protein Cln3 | Batten's disease protein Cln3, subgroup | MFS transporter superfamily |
|---|---|---|---|---|
|
UniProtKB:Q5U392
|
446 |
Interactions and Pathways
No data available
Plasmids