Community Action Needed: Please respond to the NIH RFI
Gene

prdm12b

ID
ZDB-GENE-041114-172
Name
PR domain containing 12b
Symbol
prdm12b Nomenclature History
Previous Names
  • zgc:101606
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable histone methyltransferase binding activity. Acts upstream of or within hemopoiesis; negative regulation of transcription by RNA polymerase II; and ventral spinal cord interneuron specification. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; hindbrain neural keel; midbrain neural keel; nervous system; and neurogenic placode. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 8. Orthologous to human PRDM12 (PR/SET domain 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prdm12b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 8 Alliance Neuropathy, hereditary sensory and autonomic, type VIII 616488
Associated With prdm12b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001214 SET domain
Domain IPR013087 Zinc finger C2H2-type
Family IPR017126 PR-domain zinc finger protein PRDM12
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length PR-domain zinc finger protein PRDM12 SET domain Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q5U3V3 366
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations