Gene
ndufs7
- ID
- ZDB-GENE-041111-261
- Name
- NADH:ubiquinone oxidoreductase core subunit S7
- Symbol
- ndufs7 Nomenclature History
- Previous Names
-
- fj19d10
- im:7149436
- wu:fj19d10
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in aerobic respiration; electron transport coupled proton transport; and mitochondrial respiratory chain complex I assembly. Predicted to be part of respiratory chain complex I. Is expressed in several structures, including eye; immature eye; musculature system; optic tectum; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149436 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nuclear type mitochondrial complex I deficiency 3 | Alliance | Mitochondrial complex I deficiency, nuclear type 3 | 618224 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | NADH-ubiquinone oxidoreductase, 20 Kd subunit | NADH:ubiquinone oxidoreductase-like, 20kDa subunit |
|---|---|---|---|
|
UniProtKB:F1QHE9
|
217 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndufs7-201
(1)
|
Ensembl | 948 nt | ||
| mRNA |
ndufs7-202
(1)
|
Ensembl | 884 nt | ||
| ncRNA |
ndufs7-002
(1)
|
Ensembl | 849 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-248I1 | ZFIN Curated Data | |
| Encodes | EST | fj19d10 | ||
| Encodes | EST | IMAGE:7149436 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001199912 (1) | 949 nt | ||
| Genomic | GenBank:BX279524 (1) | 157440 nt | ||
| Polypeptide | UniProtKB:F1QHE9 (1) | 217 aa |
- Ganguly, A., Padhan, D.K., Sengupta, A., Chakraborty, P., Sen, M. (2023) CCN6 influences transcription and controls mitochondrial mass and muscle organization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22815e22815
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Lee, J.Y., Park, H., Lim, W., Song, G. (2021) Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. The Science of the total environment. 771:145445
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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