Gene
ezh2
- ID
- ZDB-GENE-041111-259
- Name
- enhancer of zeste 2 polycomb repressive complex 2 subunit
- Symbol
- ezh2 Nomenclature History
- Previous Names
-
- eya2
- im:7149338
- zgc:136376
- zgc:152758
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables histone H3K27 methyltransferase activity and transcription coactivator activity. Involved in positive regulation of circadian rhythm and positive regulation of hemopoiesis. Acts upstream of or within several processes, including digestive tract development; fin regeneration; and tissue homeostasis. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; digestive system; eye; gonad; and intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149338 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Weaver syndrome | Alliance | Weaver syndrome | 277590 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001005 | SANT/Myb domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR026489 | CXC domain |
| Domain | IPR033467 | Tesmin/TSO1-like CXC domain |
| Domain | IPR041343 | Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain |
| Domain | IPR041355 | Pre-SET CXC domain |
| Domain | IPR044439 | EZH2, SET domain |
| Domain | IPR048358 | EZH1/2, MCSS domain |
| Family | IPR021654 | Histone-lysine N-methyltransferase EZH1/EZH2 |
| Family | IPR045318 | Histone-lysine N-methyltransferase EZH1/2-like |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | CXC domain | EZH1/2, MCSS domain | EZH2, SET domain | Histone-lysine N-methyltransferase EZH1/2-like | Histone-lysine N-methyltransferase EZH1/EZH2 | Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain | Pre-SET CXC domain | SANT/Myb domain | SET domain | SET domain superfamily | Tesmin/TSO1-like CXC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q08BS4
|
760 |
Interactions and Pathways
No data available
Plasmids
No data available