Gene

ezh2

ID
ZDB-GENE-041111-259
Name
enhancer of zeste 2 polycomb repressive complex 2 subunit
Symbol
ezh2 Nomenclature History
Previous Names
  • eya2
  • im:7149338
  • zgc:136376
  • zgc:152758
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Is predicted to enable promoter-specific chromatin binding activity. Involved in negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including fin regeneration; histone H3-K27 methylation; and tissue homeostasis. Predicted to be located in nucleus. Predicted to be part of ESC/E(Z) complex. Is expressed in several structures, including central nervous system; digestive system; eye; gonad; and intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in Weaver syndrome; bone cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ezh2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Weaver syndrome Alliance Weaver syndrome 277590
Associated With ezh2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001005 SANT/Myb domain
Domain IPR001214 SET domain
Domain IPR026489 CXC domain
Domain IPR033467 Tesmin/TSO1-like CXC domain
Domain IPR041343 Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain
Domain IPR041355 Pre-SET CXC domain
Family IPR021654 Histone-lysine N-methyltransferase EZH1/EZH2
Domain Details Per Protein
Protein Length CXC domain Histone-lysine N-methyltransferase EZH1/EZH2 Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain Pre-SET CXC domain SANT/Myb domain SET domain Tesmin/TSO1-like CXC domain
UniProtKB:A0A286Y9P9 770
UniProtKB:Q08BS4 760
UniProtKB:Q504B3 508
UniProtKB:X1WHS1 126
UniProtKB:A5XBQ3 217
UniProtKB:F1QQ58 760
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations