Gene

piezo1

ID

ZDB-GENE-041111-255

Name

piezo type mechanosensitive ion channel component 1 (Er blood group)

Symbol

piezo1 Nomenclature History

Previous Names

FAM38A (1)
im:7149048

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Enables mechanosensitive monoatomic ion channel activity and voltage-gated channel activity. Involved in regulation of epidermal cell division. Acts upstream of or within several processes, including cell volume homeostasis; epidermal cell division; and ventriculo bulbo valve development. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in nucleate erythrocyte and ventral mesoderm. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7149048 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With piezo1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dehydrated hereditary stomatocytosis 1	Alliance	Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema	194380
		Lymphatic malformation 6	616843
		[ER blood group system]	620207

Associated With piezo1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR031334	Piezo non-specific cation channel, R-Ras-binding domain
Domain	IPR031805	Piezo domain
Family	IPR027272	Piezo family

Domain Details Per Protein

Protein	Length	Piezo domain	Piezo family	Piezo non-specific cation channel, R-Ras-binding domain
UniProtKB:A0A8N7TDV6 InterPro	2538

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	piezo1-201 (1) Ensembl	Ensembl		7,311 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations