Gene
cox10
- ID
- ZDB-GENE-041111-239
- Name
- cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
- Symbol
- cox10 Nomenclature History
- Previous Names
-
- im:7145568
- im:7157205
- wu:fb18a03
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have farnesyltranstransferase activity. Predicted to be involved in cellular respiration and heme biosynthetic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Leigh disease and cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
mitochondrial complex IV deficiency nuclear type 3 | Alliance | Mitochondrial complex IV deficiency, nuclear type 3 | 619046 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR030470 | UbiA prenyltransferase conserved site |
Family | IPR000537 | UbiA prenyltransferase |
Family | IPR006369 | Protohaem IX farnesyltransferase |
Family | IPR016315 | Protohaem IX farnesyltransferase, mitochondria |
Homologous_superfamily | IPR044878 | UbiA prenyltransferase superfamily |
Domain Details Per Protein
Protein | Length | Protohaem IX farnesyltransferase | Protohaem IX farnesyltransferase, mitochondria | UbiA prenyltransferase | UbiA prenyltransferase conserved site | UbiA prenyltransferase superfamily |
---|---|---|---|---|---|---|
UniProtKB:F1QL30
|
447 | |||||
UniProtKB:Q08C12
|
464 |
Interactions and Pathways
No data available
Plasmids
No data available