Gene

tonsl

ID

ZDB-GENE-041111-230

Name

tonsoku-like, DNA repair protein

Symbol

tonsl Nomenclature History

Previous Names

im:7145273 (1)
zgc:171416 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable histone binding activity. Predicted to be involved in double-strand break repair via homologous recombination and replication fork processing. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nuclear replication fork. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Orthologous to human TONSL (tonsoku like, DNA repair protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Burrage et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tonsl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spondyloepimetaphyseal dysplasia, Sponastrime type	Alliance	Spondyloepimetaphyseal dysplasia, sponastrime type	271510

Associated With tonsl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR052311	MMS22L-TONSL complex component
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR002110	Ankyrin repeat
Repeat	IPR006553	Leucine-rich repeat, cysteine-containing subtype
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Leucine-rich repeat	Leucine-rich repeat, cysteine-containing subtype	Leucine-rich repeat domain superfamily	MMS22L-TONSL complex component	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat
UniProtKB:A9JR78 InterPro	1427

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tonsl-201 (1) Ensembl	Ensembl	4,822 nt	Select Tool ZFIN BLAST
mRNA	tonsl-203 (1) Ensembl	Ensembl	6,363 nt	Select Tool ZFIN BLAST
mRNA	tonsl-204 (1) Ensembl	Ensembl	6,195 nt	Select Tool ZFIN BLAST
ncRNA	tonsl-002 (1) Ensembl	Ensembl	833 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations