Gene

chd4a

ID

ZDB-GENE-041111-187

Name

chromodomain helicase DNA binding protein 4a

Symbol

chd4a Nomenclature History

Previous Names

im:7143343
si:ch211-51m24.3

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have several functions, including ATP binding activity; RNA polymerase II repressing transcription factor binding activity; and histone deacetylase binding activity. Involved in fin regeneration. Predicted to localize to NuRD complex. Is expressed in blastomere and central nervous system. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7143343 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chd4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Sifrim-Hitz-Weiss syndrome	Alliance	Sifrim-Hitz-Weiss syndrome	617159

Associated With chd4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR000330	SNF2, N-terminal
Domain	IPR000953	Chromo/chromo shadow domain
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR009462	CHD subfamily II, SANT-like domain
Domain	IPR009463	Domain of unknown function DUF1087
Domain	IPR012957	CHD, C-terminal 2
Domain	IPR012958	CHD, N-terminal
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR023780	Chromo domain
Domain	IPR049730	SNF2/RAD5-like, C-terminal helicase domain
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR016197	Chromo-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR038718	SNF2-like, N-terminal domain superfamily