Gene
galnt2
- ID
- ZDB-GENE-041111-110
- Name
- UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
- Symbol
- galnt2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within fin regeneration and regulation of bone mineralization. Predicted to be located in Golgi cisterna membrane; Golgi membrane; and extracellular region. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIt. Orthologous to human GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140357 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12860 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14540 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17374 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24933 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28108 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| zju110Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital disorder of glycosylation type IIt | Alliance | Congenital disorder of glycosylation, type IIt | 618885 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycosyltransferase 2-like | N-acetylgalactosaminyltransferase | Nucleotide-diphospho-sugar transferases | Ricin B, lectin domain | Ricin B-like lectins |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B826 | InterPro | 565 | |||||
| UniProtKB:B0V0U4 | InterPro | 559 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
galnt2-201
(1)
|
Ensembl | 4,104 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-162B3 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140357 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128351 (1) | 4104 nt | ||
| Genomic | GenBank:CR762497 (1) | 258636 nt | ||
| Polypeptide | UniProtKB:A0A8M3B826 (1) | 565 aa |
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Sztal, T.E., McKaige, E.A., Williams, C., Ruparelia, A.A., Bryson-Richardson, R.J. (2018) Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. PLoS Genetics. 14:e1007212
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ma, Z., Zhu, P., Pang, M., Guo, L., Chang, N., Zheng, J., Zhu, X., Gao, C., Huang, H., Cui, Z., Xiong, J.W., Peng, J., Chen, J. (2017) A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Scientific Reports. 7:10381
- Stevenson, N.L., Bergen, D.J.M., Skinner, R.E.H., Kague, E., Martin-Silverstone, E., Robson Brown, K.A., Hammond, C.L., Stephens, D.J. (2017) Giantin knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression. Journal of Cell Science. 130(24):4132-4143
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
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