Gene

itsn2a

ID

ZDB-GENE-041014-84

Name

intersectin 2a

Symbol

itsn2a Nomenclature History

Previous Names

DKEY-266K12.2 (1)
si:dkey-266k12.1

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable molecular adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis. Predicted to act upstream of or within endocytosis and intracellular signal transduction. Predicted to be located in cell projection and synapse. Predicted to be active in cytoplasm; intracellular vesicle; and presynaptic membrane. Orthologous to human ITSN2 (intersectin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itsn2a Human Ortholog

No data available

Associated With itsn2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000008	C2 domain
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000261	EH domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002048	EF-hand domain
Domain	IPR035737	Intersectin-2, first SH3 domain
Domain	IPR035740	Intersectin-2, fourth SH3 domain
Family	IPR051480	Endocytic & GEF Adapter
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	EF-hand domain	EF-hand domain pair	EH domain	Endocytic & GEF Adapter	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Intersectin-2, first SH3 domain	Intersectin-2, fourth SH3 domain	PH-like domain superfamily	Pleckstrin homology domain	SH3 domain	SH3-like domain superfamily
UniProtKB:U3JA74 InterPro	1639
UniProtKB:B0V162 InterPro	1665
UniProtKB:A0A8M9PHG8 InterPro	1163
UniProtKB:A0A8M9PBV5 InterPro	1666
UniProtKB:A0A8M9PSW3 InterPro	1106

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	itsn2a-201 (1) Ensembl	Ensembl	5,052 nt	Select Tool ZFIN BLAST
mRNA	itsn2a-203 (1) Ensembl	Ensembl	5,204 nt	Select Tool ZFIN BLAST
mRNA	itsn2a-204 (1) Ensembl	Ensembl	1,599 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000009688 (1) Ensembl	Ensembl	611 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations