Gene
lmx1a
- ID
- ZDB-GENE-041014-332
- Name
- LIM homeobox transcription factor 1, alpha
- Symbol
- lmx1a Nomenclature History
- Previous Names
-
- si:ch211-260g14.3
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7. Is expressed in brain; cranial ganglion; and otic vesicle. Orthologous to human LMX1A (LIM homeobox transcription factor 1 alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Seifinejad et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 7 | Alliance | Deafness, autosomal dominant 7 | 601412 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Lmx1a, first LIM domain | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PSR7
|
347 | ||||||
|
UniProtKB:A0A8M2B7U0
|
268 | ||||||
|
UniProtKB:Q5RI65
|
366 |
Interactions and Pathways
No data available
Plasmids
No data available