Gene
lmx1a
- ID
- ZDB-GENE-041014-332
- Name
- LIM homeobox transcription factor 1, alpha
- Symbol
- lmx1a Nomenclature History
- Previous Names
-
- si:ch211-260g14.3
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; cranial ganglion; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7. Orthologous to human LMX1A (LIM homeobox transcription factor 1 alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Seifinejad et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1653 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9422 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32304 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37086 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 7 | Alliance | Deafness, autosomal dominant 7 | 601412 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Lmx1a, first LIM domain | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PSR7 | InterPro | 347 | ||||||
| UniProtKB:A0A8M2B7U0 | InterPro | 268 | ||||||
| UniProtKB:Q5RI65 | InterPro | 366 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260G14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025498 (1) | 1374 nt | ||
| Genomic | GenBank:BX296562 (1) | 129328 nt | ||
| Polypeptide | UniProtKB:Q5RI65 (1) | 366 aa |
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Seifinejad, A., Li, S., Mikhail, C., Vassalli, A., Pradervand, S., Arribat, Y., Pezeshgi Modarres, H., Allen, B., John, R.M., Amati, F., Tafti, M. (2019) Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proceedings of the National Academy of Sciences of the United States of America. 116(34):17061-17070
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
- Wang, F., Chen, X., Shi, W., Yao, L., Gao, M., Yang, Y., Hao, A. (2015) Zdhhc15b Regulates Differentiation of Diencephalic Dopaminergic Neurons in Zebrafish. Journal of cellular biochemistry. 116(12):2980-91
- Burzynski, G.M., Reed, X., Maragh, S., Matsui, T., and McCallion, A.S. (2013) Integration of genomic and functional approaches reveals enhancers at LMX1A and LMX1B. Molecular genetics and genomics : MGG. 288(11):579-89
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