Gene

prg4b

ID

ZDB-GENE-041014-324

Name

proteoglycan 4b

Symbol

prg4b Nomenclature History

Previous Names

prg4
si:dkey-97o5.3
zgc:122988

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity; polysaccharide binding activity; and scavenger receptor activity. Predicted to be involved in immune response. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Askary et al., 2016

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prg4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
camptodactyly-arthropathy-coxa vara-pericarditis syndrome	Alliance	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome	208250

Associated With prg4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018486	Hemopexin, conserved site
Domain	IPR000585	Hemopexin-like domain
Domain	IPR001212	Somatomedin B domain
Domain	IPR020436	Somatomedin B domain, chordata
Homologous_superfamily	IPR036024	Somatomedin B-like domain superfamily
Homologous_superfamily	IPR036375	Hemopexin-like domain superfamily
Repeat	IPR018487	Hemopexin-like repeats

Domain Details Per Protein

Protein	Length	Hemopexin, conserved site	Hemopexin-like domain	Hemopexin-like domain superfamily	Hemopexin-like repeats	Somatomedin B domain	Somatomedin B domain, chordata	Somatomedin B-like domain superfamily
UniProtKB:F1REF9 InterPro	711
UniProtKB:A0A8M2B7K8 InterPro	740

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prg4b-201 (1) Ensembl	Havana	558 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prg4b-202 (1) Ensembl	Havana	2826 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations