Gene

met

ID
ZDB-GENE-041014-1
Name
MET proto-oncogene, receptor tyrosine kinase
Symbol
met Nomenclature History
Previous Names
  • c-met (1)
  • cmet (1)
  • don
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have hepatocyte growth factor-activated receptor activity. Involved in several processes, including generation of neurons; gland development; and pectoral fin development. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in several structures, including anterior neural rod; endocrine system; gut; musculature system; and nervous system. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
26 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With met Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 97 Alliance ?Deafness, autosomal recessive 97 616705
hepatocellular carcinoma Alliance Hepatocellular carcinoma, childhood type, somatic 114550
papillary renal cell carcinoma Alliance Renal cell carcinoma, papillary, 1, familial and somatic 605074
{Osteofibrous dysplasia, susceptibility to} 607278
Associated With met Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001627 Sema domain
Domain IPR002909 IPT domain
Domain IPR016201 PSI domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR016244 Tyrosine-protein kinase, HGF/MSP receptor
Family IPR031148 Plexin family
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036352 Sema domain superfamily
Repeat IPR002165 Plexin repeat
Domain Details Per Protein
Protein Length Immunoglobulin E-set Immunoglobulin-like fold IPT domain Plexin family Plexin repeat Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily PSI domain Sema domain Sema domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, HGF/MSP receptor WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:F1QLR7 1382
UniProtKB:A0A0B5JQ16 933
UniProtKB:Q90ZG4 143
UniProtKB:Q64GK4 1382
UniProtKB:A0M8V8 395
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations