ZFIN is now using GRCz12tu for Genomic Data
Gene
dut
- ID
- ZDB-GENE-041010-93
- Name
- deoxyuridine triphosphatase
- Symbol
- dut Nomenclature History
- Previous Names
-
- wu:fa28d11
- zgc:103772
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable dUTP diphosphatase activity and magnesium ion binding activity. Predicted to be involved in dUMP biosynthetic process and dUTP catabolic process. Predicted to be located in cytoplasm. Is expressed in digestive system; nervous system; neural plate; pectoral fin; and tail bud. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human DUT (deoxyuridine triphosphatase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6904947 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Perey-Simon et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bone marrow failure and diabetes mellitus syndrome | 620044 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Deoxyuridine triphosphate nucleotidohydrolase | dUTPase-like | dUTPase-like superfamily | dUTPase, trimeric |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PA15 | InterPro | 165 | ||||
| UniProtKB:A0A8M9P120 | InterPro | 168 | ||||
| UniProtKB:Q5XJ23 | InterPro | 187 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers