Gene
serpina7
- ID
- ZDB-GENE-041010-47
- Name
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
- Symbol
- serpina7 Nomenclature History
- Previous Names
-
- wu:fb66f08
- wu:fb68e04
- zgc:103617
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be active in extracellular space. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to several human genes including SERPINA5 (serpin family A member 5) and SERPINA7 (serpin family A member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103617 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Thyroxine-binding globulin QTL] | 300932 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QE74 | InterPro | 425 | ||||||
| UniProtKB:F8W5C3 | InterPro | 410 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpina7-201
(1)
|
Ensembl | 1,441 nt | ||
| mRNA |
serpina7-202
(1)
|
Ensembl | 1,499 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-186E20 | ZFIN Curated Data | |
| Encodes | EST | fb66f08 | ||
| Encodes | EST | fb68e04 | ||
| Encodes | cDNA | MGC:103617 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174258 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174261 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191380 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105589 (1) | 1491 nt | ||
| Genomic | GenBank:AL844899 (1) | 167857 nt | ||
| Polypeptide | UniProtKB:A0A8M9QE74 (1) | 425 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SERPINA7 | X | Amino acid sequence comparison (1) |
- Karampelias, C., Rezanejad, H., Rosko, M., Duan, L., Lu, J., Pazzagli, L., Bertolino, P., Cesta, C.E., Liu, X., Korbutt, G.S., Andersson, O. (2021) Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Nature communications. 12:3362
- Wang, W.Q., Qiu, S.W., Huang, S.S., Wang, G.J., Han, M.Y., Kang, D.Y., Yuan, Y.Y., Gao, X., Dai, P. (2021) Transcriptome analysis of the early stage ifnlr1-mutant zebrafish indicates the immune response to auditory dysfunction. Gene expression patterns : GEP. 43:119229
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- El Ouaamari, A., Dirice, E., Gedeon, N., Hu, J., Zhou, J.Y., Shirakawa, J., Hou, L., Goodman, J., Karampelias, C., Qiang, G., Boucher, J., Martinez, R., Gritsenko, M.A., De Jesus, D.F., Kahraman, S., Bhatt, S., Smith, R.D., Beer, H.D., Jungtrakoon, P., Gong, Y., Goldfine, A.B., Liew, C.W., Doria, A., Andersson, O., Qian, W.J., Remold-O'Donnell, E., Kulkarni, R.N. (2016) SerpinB1 Promotes Pancreatic β Cell Proliferation. Cell Metabolism. 23(1):194-205
- Shan, Y., Zhang, Y., Zhuo, X., Li, X., Peng, J., Fang, W. (2016) Matrix metalloproteinase-9 plays a role in protecting zebrafish from lethal infection with Listeria monocytogenes by enhacing macrophage migration. Fish & shellfish immunology. 54:179-87
- Andreeva, A.M., Lamas, N.E., Serebryakova, M.V., Ryabtseva, I.P., Bolshakov, V.V. (2015) Reorganization of Low-Molecular-Weight Fraction of Plasma Proteins in the Annual Cycle of Cyprinidae. Biochemistry. Biokhimiia. 80:208-218
- Hu, P., Liu, M., Zhang, D., Wang, J., Niu, H., Liu, Y., Wu, Z., Han, B., Zhai, W., Shen, Y., Chen, L. (2015) Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish. Nucleic acids research. 43(19):9198-213
- Lü, A., Hu, X., Wang, Y., Shen, X., Li, X., Zhu, A., Tian, J., Ming, Q., and Feng, Z. (2014) iTRAQ analysis of gill proteins from the zebrafish (Danio rerio) infected with Aeromonas hydrophila. Fish & shellfish immunology. 36(1):229-239
- Babaei, F., Ramalingam, R., Tavendale, A., Liang, Y., Yan, L.S., Ajuh, P., Cheng, S.H., and Lam, Y.W. (2013) Novel Blood Collection Method Allows Plasma Proteome Analysis from Single Zebrafish. Journal of Proteome Research. 12(4):1580-90
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