Gene
ppp2r2bb
- ID
- ZDB-GENE-041010-39
- Name
- protein phosphatase 2, regulatory subunit B, beta b
- Symbol
- ppp2r2bb Nomenclature History
- Previous Names
-
- ppp2r2b
- zgc:101861
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable protein phosphatase regulator activity. Predicted to be located in cytoskeleton and membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101861 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 12 | Alliance | Spinocerebellar ataxia 12 | 604326 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018067 | Protein phosphatase 2A regulatory subunit PR55, conserved site |
| Family | IPR000009 | Protein phosphatase 2A regulatory subunit PR55 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
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Domain Details Per Protein
| Protein | Length | Protein phosphatase 2A regulatory subunit PR55 | Protein phosphatase 2A regulatory subunit PR55, conserved site | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8Q610
|
446 | |||||
|
UniProtKB:A0A8M9PCQ6
|
433 | |||||
|
UniProtKB:A0A0R4IEA6
|
443 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp2r2bb-201
(1)
|
Ensembl | 491 nt | ||
| mRNA |
ppp2r2bb-202
(1)
|
Ensembl | 1,920 nt | ||
| mRNA |
ppp2r2bb-203
(1)
|
Ensembl | 1,694 nt | ||
| mRNA |
ppp2r2bb-204
(1)
|
Ensembl | 1,302 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-209N22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-270B18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-283M17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101861 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030122 (1) | 2984 nt | ||
| Genomic | GenBank:BX005397 (2) | 156273 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q610 (1) | 446 aa |
- Spreafico, M., Gruszka, A.M., Valli, D., Mazzola, M., Deflorian, G., Quintè, A., Totaro, M.G., Battaglia, C., Alcalay, M., Marozzi, A., Pistocchi, A. (2020) HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Frontiers in cell and developmental biology. 8:844
- Lagman, D., Franzén, I.E., Eggert, J., Larhammar, D., Abalo, X.M. (2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. BMC Evolutionary Biology. 16:124
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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