Gene
mettl5
- ID
- ZDB-GENE-041010-21
- Name
- methyltransferase 5, N6-adenosine
- Symbol
- mettl5 Nomenclature History
- Previous Names
-
- im:7137598
- zgc:103655 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in positive regulation of translation; rRNA methylation; and stem cell differentiation. Predicted to act upstream of or within methylation. Predicted to be located in nucleus; postsynapse; and presynapse. Used to study autosomal recessive intellectual developmental disorder 72. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137598 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Richard et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 72 | Alliance | Intellectual developmental disorder, autosomal recessive 72 | 618665 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002052 | DNA methylase, N-6 adenine-specific, conserved site |
| Domain | IPR007848 | Methyltransferase small domain |
| Family | IPR051720 | rRNA N6-Adenosine-Methyltransferase/Polyamine Synthase |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
Domain Details Per Protein
| Protein | Length | DNA methylase, N-6 adenine-specific, conserved site | Methyltransferase small domain | rRNA N6-Adenosine-Methyltransferase/Polyamine Synthase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|
|
UniProtKB:F1QVR8
|
207 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mettl5-201
(1)
|
Ensembl | 1,090 nt | ||
| mRNA |
mettl5-203
(1)
|
Ensembl | 881 nt | ||
| mRNA |
mettl5-205
(1)
|
Ensembl | 5,511 nt | ||
| ncRNA |
mettl5-003
(1)
|
Ensembl | 814 nt | ||
| ncRNA |
mettl5-004
(1)
|
Ensembl | 779 nt |
Interactions and Pathways
No data available
Plasmids
No data available