Gene

gss

ID
ZDB-GENE-041010-208
Name
glutathione synthetase
Symbol
gss Nomenclature History
Previous Names
  • sb:cb814
  • zgc:101574
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in head kidney; lens; pronephric duct; and solid lens vesicle. Orthologous to human GSS (glutathione synthetase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gss Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
glutathione synthetase deficiency Alliance Glutathione synthetase deficiency 266130
hemolytic anemia due to glutathione synthetase deficiency Alliance Hemolytic anemia due to glutathione synthetase deficiency 231900
Associated With gss Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004887 Glutathione synthase, substrate-binding domain
Family IPR005615 Glutathione synthase
Homologous_superfamily IPR014042 Glutathione synthase, alpha-helical
Homologous_superfamily IPR014049 Glutathione synthase, N-terminal, eukaryotic
Homologous_superfamily IPR014709 Glutathione synthase, C-terminal, eukaryotic
Homologous_superfamily IPR016185 Pre-ATP-grasp domain superfamily
Homologous_superfamily IPR037013 Glutathione synthase, substrate-binding domain superfamily
Domain Details Per Protein
Protein Length Glutathione synthase Glutathione synthase, alpha-helical Glutathione synthase, C-terminal, eukaryotic Glutathione synthase, N-terminal, eukaryotic Glutathione synthase, substrate-binding domain Glutathione synthase, substrate-binding domain superfamily Pre-ATP-grasp domain superfamily
UniProtKB:A0A2R8QGJ2 475
UniProtKB:Q5XJT8 475
UniProtKB:F1RC64 475
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations