Gene

gla

ID
ZDB-GENE-041010-207
Name
galactosidase, alpha
Symbol
gla Nomenclature History
Previous Names
  • zgc:101584
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gla Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fabry disease Alliance Fabry disease 301500
Fabry disease Alliance Fabry disease, cardiac variant 301500
Associated With gla Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000111 Glycoside hydrolase family 27/36, conserved site
Domain IPR035373 Alpha galactosidase A, C-terminal beta-sandwich domain
Family IPR002241 Glycoside hydrolase, family 27
Homologous_superfamily IPR013780 Glycosyl hydrolase, all-beta
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Homologous_superfamily IPR017853 Glycoside hydrolase superfamily
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel Alpha galactosidase A, C-terminal beta-sandwich domain Glycoside hydrolase, family 27 Glycoside hydrolase family 27/36, conserved site Glycoside hydrolase superfamily Glycosyl hydrolase, all-beta
UniProtKB:Q5XJT6 338
UniProtKB:F1Q5G5 409
UniProtKB:F1QR55 330
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations