Gene

gla

ID

ZDB-GENE-041010-207

Name

galactosidase, alpha

Symbol

gla Nomenclature History

Previous Names

zgc:101584

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process and oligosaccharide metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101584 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gla Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fabry disease	Alliance	Fabry disease	301500
Fabry disease	Alliance	Fabry disease, cardiac variant	301500

Associated With gla Via Experimental Models

Human Disease	Fish	Conditions	Citations
Fabry disease	gla^huh1/huh1 (AB/TU)	standard conditions	Elsaid et al., 2023
Fabry disease	gla^huh1/huh1	standard conditions	Elsaid et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000111	Glycoside hydrolase family 27/36, conserved site
Domain	IPR035373	Alpha galactosidase A, C-terminal beta-sandwich domain
Family	IPR002241	Glycoside hydrolase, family 27
Homologous_superfamily	IPR013780	Glycosyl hydrolase, all-beta
Homologous_superfamily	IPR013785	Aldolase-type TIM barrel
Homologous_superfamily	IPR017853	Glycoside hydrolase superfamily