Gene

tpk1

ID

ZDB-GENE-041010-176

Name

thiamin pyrophosphokinase 1

Symbol

tpk1 Nomenclature History

Previous Names

zgc:101685 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:101685 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpk1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Thiamine metabolism dysfunction syndrome 5 (episodic encephalopathy type)	614458

Associated With tpk1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007371	Thiamin pyrophosphokinase, catalytic domain
Domain	IPR007373	Thiamin pyrophosphokinase, thiamin-binding domain
Family	IPR006282	Thiamin pyrophosphokinase
Family	IPR016966	Thiamin pyrophosphokinase, eukaryotic
Homologous_superfamily	IPR036371	Thiamin pyrophosphokinase, thiamin-binding domain superfamily
Homologous_superfamily	IPR036759	Thiamin pyrophosphokinase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Thiamin pyrophosphokinase	Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, catalytic domain superfamily	Thiamin pyrophosphokinase, eukaryotic	Thiamin pyrophosphokinase, thiamin-binding domain	Thiamin pyrophosphokinase, thiamin-binding domain superfamily
UniProtKB:Q5XJQ1 InterPro	257
UniProtKB:F1RBJ9 InterPro	257

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpk1-201 (1) Ensembl	Havana	1964 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpk1-202 (1) Ensembl	Havana	562 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations