Gene
tpk1
- ID
- ZDB-GENE-041010-176
- Name
- thiamin pyrophosphokinase 1
- Symbol
- tpk1 Nomenclature History
- Previous Names
-
- zgc:101685 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Predicted to act upstream of or within phosphorylation and thiamine metabolic process. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101685 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Thiamine metabolism dysfunction syndrome 5 (episodic encephalopathy type) | 614458 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007371 | Thiamin pyrophosphokinase, catalytic domain |
| Domain | IPR007373 | Thiamin pyrophosphokinase, thiamin-binding domain |
| Family | IPR006282 | Thiamin pyrophosphokinase |
| Family | IPR016966 | Thiamin pyrophosphokinase, eukaryotic |
| Homologous_superfamily | IPR036371 | Thiamin pyrophosphokinase, thiamin-binding domain superfamily |
| Homologous_superfamily | IPR036759 | Thiamin pyrophosphokinase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | Thiamin pyrophosphokinase | Thiamin pyrophosphokinase, catalytic domain | Thiamin pyrophosphokinase, catalytic domain superfamily | Thiamin pyrophosphokinase, eukaryotic | Thiamin pyrophosphokinase, thiamin-binding domain | Thiamin pyrophosphokinase, thiamin-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5XJQ1
|
257 | ||||||
|
UniProtKB:F1RBJ9
|
257 |
Interactions and Pathways
No data available
Plasmids
No data available