Gene

ank2b

ID
ZDB-GENE-041010-165
Name
ankyrin 2b, neuronal
Symbol
ank2b Nomenclature History
Previous Names
  • ank2
  • zgc:101738 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have aspartic-type endopeptidase activity. Predicted to be involved in proteolysis and signal transduction. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Is expressed in central nervous system; cranial ganglion; optic vesicle; and retinal ganglion cell layer. Orthologous to human ANK2 (ankyrin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ank2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ankyrin-B-related cardiac arrhythmia Alliance Cardiac arrhythmia, ankyrin-B-related 600919
ankyrin-B-related cardiac arrhythmia Alliance Long QT syndrome 4 600919
Associated With ank2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001969 Aspartic peptidase, active site
Domain IPR000488 Death domain
Domain IPR000906 ZU5 domain
Domain IPR040745 Ankyrin, UPA domain
Family IPR051165 Multifunctional Ankyrin Repeat Domain-Containing Protein
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily Ankyrin, UPA domain Aspartic peptidase, active site Death domain Death-like domain superfamily Multifunctional Ankyrin Repeat Domain-Containing Protein ZU5 domain
UniProtKB:A0A8M9Q7R7 3532
UniProtKB:A0A8M9Q1F0 3626
UniProtKB:A0A8M9QBV6 3608
UniProtKB:A0A8M9PNT0 3622
UniProtKB:A0A8M9Q7R2 3603
UniProtKB:A0A8M9PNV7 1513
UniProtKB:A0A8M9QBY0 2668
UniProtKB:A0A8M9Q7T1 1991
UniProtKB:A0A8M9QGV2 3608
UniProtKB:A0A8M9Q1I9 2002
UniProtKB:A0A8M9PNS3 3630
UniProtKB:A0A8M9QGU1 3631
UniProtKB:A0A8M1PAL4 1754
UniProtKB:A0A8M9QGV9 3601
UniProtKB:A0A8M9QGW4 3508
UniProtKB:A0A8M9Q7S2 3308
UniProtKB:A0A8M9Q1H0 3563
UniProtKB:A0A8M9PNT8 3589
UniProtKB:A0A8M9QBW8 3502
UniProtKB:A0A8M9PNT4 3604
UniProtKB:A0A8M9Q1F7 3620
UniProtKB:A0A8M9QBW2 3596
UniProtKB:A0A8M9Q7S6 2679
UniProtKB:A0A8M9PNU3 3483
UniProtKB:A0A8M9QBY5 1524
UniProtKB:A0A8M9QGX0 3276
UniProtKB:A0A8M9Q1G4 3604
UniProtKB:A0A8M9QGX6 2669
UniProtKB:A0A8M9Q1H7 3482
UniProtKB:A0A8M9PNV1 2598
UniProtKB:A0A8M9QBV0 3622
UniProtKB:A0A8M9QBX3 3275
UniProtKB:A0A8M9Q7Q0 3633
UniProtKB:A0A8M9Q1I2 2680
UniProtKB:A0A8M9Q1E3 3634
UniProtKB:A0A8M9QGU6 3623
UniProtKB:A0A8M9Q7Q4 3623
UniProtKB:A0A8M9Q7Q9 3616
UniProtKB:A0A8M9PNU7 2805
UniProtKB:A0A8M9QGY1 1882
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ank2b-201 (1) Ensembl 1,495 nt
mRNA ank2b-202 (1) Ensembl 294 nt
mRNA ank2b-203 (1) Ensembl 713 nt
mRNA ank2b-204 (1) Ensembl 1,401 nt
mRNA ank2b-205 (1) Ensembl 11,061 nt
mRNA ank2b-206 (1) Ensembl 6,814 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations