Gene
rnf4
- ID
- ZDB-GENE-041008-246
- Name
- ring finger protein 4
- Symbol
- rnf4 Nomenclature History
- Previous Names
-
- im:7142942
- im:7144630
- si:ch211-159i8.3
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Acts upstream of with a positive effect on granulocyte differentiation. Predicted to colocalize with PML body. Orthologous to human RNF4 (ring finger protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wang et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-rnf4 | N/A | Wang et al., 2018 |
TALEN1-rnf4 | Wang et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | E3 ubiquitin-protein ligase RNF4 | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
---|---|---|---|---|---|---|
UniProtKB:A0A0R4IUS5 | InterPro | 184 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-159I8 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7142942 | Thisse et al., 2004 | |
Encodes | EST | IMAGE:7144630 | Thisse et al., 2004 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001386248 (1) | 1349 nt | ||
Genomic | GenBank:BX004830 (1) | 201070 nt | ||
Polypeptide | UniProtKB:A0A0R4IUS5 (1) | 184 aa |
- Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., Goodhill, G.J., Richards, R.I., Pederson, S.M., Lardelli, M. (2021) Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome. Frontiers in genetics. 12:625466
- Huang, L., Urasaki, A., Inagaki, N. (2019) Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Scientific Reports. 9:1799
- Wang, L., Liu, X., Wang, H., Yuan, H., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2018) RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPα axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9):4930-4940
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Silva, I. A. L., Conceição, N., Michou, L., Cancela, M. L. (2014) Can zebrafish be a valid model to study Paget's disease of bone?. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):678-688
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