ZFIN is now using GRCz12tu for Genomic Data
Gene
top2b
- ID
- ZDB-GENE-041008-136
- Name
- DNA topoisomerase II beta
- Symbol
- top2b Nomenclature History
- Previous Names
-
- im:7138121 (1)
- si:dkey-98n4.1
- wu:fc38e02
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Acts upstream of or within axonogenesis and sensory system development. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; eye; immature eye; and pharyngeal arch 3-7. Orthologous to human TOP2B (DNA topoisomerase II beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138121 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| B-cell immunodeficiency, distal limb anomalies, and urogenital malformations | 609296 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018522 | DNA topoisomerase, type IIA, conserved site |
| Domain | IPR002205 | DNA topoisomerase, type IIA, domain A |
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR006171 | TOPRIM domain |
| Domain | IPR012542 | DTHCT |
| Domain | IPR013506 | DNA topoisomerase, type IIA, subunit B, domain 2 |
| Domain | IPR031660 | C-terminal associated domain of TOPRIM |
| Domain | IPR034157 | DNA topoisomerase 2, TOPRIM domain |
| Family | IPR001154 | DNA topoisomerase II, eukaryotic-type |
| Family | IPR001241 | DNA topoisomerase, type IIA |
| Family | IPR050634 | DNA Topoisomerase II |
| Homologous_superfamily | IPR013757 | DNA topoisomerase, type IIA, alpha-helical domain superfamily |
| Homologous_superfamily | IPR013758 | DNA topoisomerase, type IIA, domain A, alpha-beta |
| Homologous_superfamily | IPR013759 | DNA topoisomerase, type IIA, subunit B, C-terminal |
| Homologous_superfamily | IPR013760 | DNA topoisomerase, type IIA-like domain superfamily |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C-terminal associated domain of TOPRIM | DNA topoisomerase 2, TOPRIM domain | DNA Topoisomerase II | DNA topoisomerase II, eukaryotic-type | DNA topoisomerase, type IIA | DNA topoisomerase, type IIA, alpha-helical domain superfamily | DNA topoisomerase, type IIA, conserved site | DNA topoisomerase, type IIA, domain A | DNA topoisomerase, type IIA, domain A, alpha-beta | DNA topoisomerase, type IIA-like domain superfamily | DNA topoisomerase, type IIA, subunit B, C-terminal | DNA topoisomerase, type IIA, subunit B, domain 2 | DTHCT | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | TOPRIM domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B6J3 | InterPro | 1613 | ||||||||||||||||||
| UniProtKB:Q1LUT2 | InterPro | 1618 | ||||||||||||||||||
| UniProtKB:A0AB32T5X6 | InterPro | 1525 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers