Gene
top2b
- ID
- ZDB-GENE-041008-136
- Name
- DNA topoisomerase II beta
- Symbol
- top2b Nomenclature History
- Previous Names
-
- im:7138121 (1)
- si:dkey-98n4.1
- wu:fc38e02
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Acts upstream of or within axonogenesis and sensory system development. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Predicted to be active in nucleus. Is expressed in brain; eye; immature eye; and pharyngeal arch 3-7. Orthologous to human TOP2B (DNA topoisomerase II beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138121 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020645Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020647Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028010Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s380 | Allele with one point mutation | Acceptor Splice Site of Exon 11 | Frameshift, Premature Stop | ENU | |
| sa11711 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23498 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-top2b | N/A | Nevin et al., 2011 |
| MO2-top2b | N/A | Xia et al., 2019 |
| MO3-top2b | N/A | Xia et al., 2019 |
| MO4-top2b | N/A | Geng et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| B-cell immunodeficiency, distal limb anomalies, and urogenital malformations | 609296 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018522 | DNA topoisomerase, type IIA, conserved site |
| Domain | IPR002205 | DNA topoisomerase, type IIA, domain A |
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR006171 | TOPRIM domain |
| Domain | IPR012542 | DTHCT |
| Domain | IPR013506 | DNA topoisomerase, type IIA, subunit B, domain 2 |
| Domain | IPR031660 | C-terminal associated domain of TOPRIM |
| Domain | IPR034157 | DNA topoisomerase 2, TOPRIM domain |
| Family | IPR001154 | DNA topoisomerase II, eukaryotic-type |
| Family | IPR001241 | DNA topoisomerase, type IIA |
| Family | IPR050634 | DNA Topoisomerase II |
| Homologous_superfamily | IPR013757 | DNA topoisomerase, type IIA, alpha-helical domain superfamily |
| Homologous_superfamily | IPR013758 | DNA topoisomerase, type IIA, domain A, alpha-beta |
| Homologous_superfamily | IPR013759 | DNA topoisomerase, type IIA, subunit B, C-terminal |
| Homologous_superfamily | IPR013760 | DNA topoisomerase, type IIA-like domain superfamily |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C-terminal associated domain of TOPRIM | DNA topoisomerase 2, TOPRIM domain | DNA Topoisomerase II | DNA topoisomerase II, eukaryotic-type | DNA topoisomerase, type IIA | DNA topoisomerase, type IIA, alpha-helical domain superfamily | DNA topoisomerase, type IIA, conserved site | DNA topoisomerase, type IIA, domain A | DNA topoisomerase, type IIA, domain A, alpha-beta | DNA topoisomerase, type IIA-like domain superfamily | DNA topoisomerase, type IIA, subunit B, C-terminal | DNA topoisomerase, type IIA, subunit B, domain 2 | DTHCT | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | TOPRIM domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B6J3 | InterPro | 1613 | ||||||||||||||||||
| UniProtKB:Q1LUT2 | InterPro | 1618 | ||||||||||||||||||
| UniProtKB:A0AB32T5X6 | InterPro | 1525 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-185O22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-98N4 | ZFIN Curated Data | |
| Encodes | EST | fc38e02 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7138121 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045191 (1) | 4857 nt | ||
| Genomic | GenBank:CR391921 (1) | 132783 nt | ||
| Polypeptide | UniProtKB:Q1LUT2 (1) | 1618 aa |
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Wang, Y., Lu, X., Wang, X., Qiu, Q., Zhu, P., Ma, L., Ma, X., Herrmann, J., Lin, X., Wang, W., Xu, X. (2021) atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity. Circulation research. 129(8):e166-e182
- Hou, J., Liu, H., Zhang, S., Liu, X., Hayat, T., Alsaedi, A., Wang, X. (2019) Mechanism of toxic effects of Nano-ZnO on cell cycle of zebrafish (Danio rerio). Chemosphere. 229:206-213
- Xia, W., Hu, J., Ma, J., Huang, J., Jing, T., Deng, L., Zhang, J., Jiang, N., Ma, D., Ma, Z. (2019) Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway. FEBS letters. 593(15):2008-2018
- Asnani, A., Zheng, B., Liu, Y., Wang, Y., Chen, H.H., Vohra, A., Chi, A., Cornella-Taracido, I., Wang, H., Johns, D.G., Sosnovik, D.E., Peterson, R.T. (2018) Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity. JCI insight. 3(1)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Leontovich, A.A., Intine, R.V., Sarras, M.P. (2016) Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Journal of Diabetes Research. 2016:2860780
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Nevin, L.M., Xiao, T., Staub, W., and Baier, H. (2011) Topoisomerase II{beta} is required for lamina-specific targeting of retinal ganglion cell axons and dendrites. Development (Cambridge, England). 138(12):2457-2465
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