Gene
top2b
- ID
- ZDB-GENE-041008-136
- Name
- DNA topoisomerase II beta
- Symbol
- top2b Nomenclature History
- Previous Names
-
- im:7138121 (1)
- si:dkey-98n4.1
- wu:fc38e02
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Acts upstream of or within axonogenesis and sensory system development. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Predicted to be active in nucleus. Is expressed in brain; eye; immature eye; and pharyngeal arch 3-7. Orthologous to human TOP2B (DNA topoisomerase II beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138121 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| B-cell immunodeficiency, distal limb anomalies, and urogenital malformations | 609296 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018522 | DNA topoisomerase, type IIA, conserved site |
| Domain | IPR002205 | DNA topoisomerase, type IIA, domain A |
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR006171 | TOPRIM domain |
| Domain | IPR012542 | DTHCT |
| Domain | IPR013506 | DNA topoisomerase, type IIA, subunit B, domain 2 |
| Domain | IPR031660 | C-terminal associated domain of TOPRIM |
| Domain | IPR034157 | DNA topoisomerase 2, TOPRIM domain |
| Family | IPR001154 | DNA topoisomerase II, eukaryotic-type |
| Family | IPR001241 | DNA topoisomerase, type IIA |
| Family | IPR050634 | DNA Topoisomerase II |
| Homologous_superfamily | IPR013757 | DNA topoisomerase, type IIA, alpha-helical domain superfamily |
| Homologous_superfamily | IPR013758 | DNA topoisomerase, type IIA, domain A, alpha-beta |
| Homologous_superfamily | IPR013759 | DNA topoisomerase, type IIA, subunit B, C-terminal |
| Homologous_superfamily | IPR013760 | DNA topoisomerase, type IIA-like domain superfamily |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
Domain Details Per Protein
| Protein | Length | C-terminal associated domain of TOPRIM | DNA topoisomerase 2, TOPRIM domain | DNA Topoisomerase II | DNA topoisomerase II, eukaryotic-type | DNA topoisomerase, type IIA | DNA topoisomerase, type IIA, alpha-helical domain superfamily | DNA topoisomerase, type IIA, conserved site | DNA topoisomerase, type IIA, domain A | DNA topoisomerase, type IIA, domain A, alpha-beta | DNA topoisomerase, type IIA-like domain superfamily | DNA topoisomerase, type IIA, subunit B, C-terminal | DNA topoisomerase, type IIA, subunit B, domain 2 | DTHCT | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | TOPRIM domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B6J3
|
1613 | ||||||||||||||||||
|
UniProtKB:Q1LUT2
|
1618 |
Interactions and Pathways
No data available
Plasmids
No data available