Gene
map3k7
- ID
- ZDB-GENE-041001-135
- Name
- mitogen-activated protein kinase kinase kinase 7
- Symbol
- map3k7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within blood vessel morphogenesis. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110612 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontometaphyseal dysplasia 2 | Alliance | Frontometaphyseal dysplasia 2 | 617137 |
| Cardiospondylocarpofacial syndrome | 157800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Family | IPR049637 | Mitogen-activated protein kinase kinase kinase 7 |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitogen-activated protein kinase kinase kinase 7 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AT57 | InterPro | 578 | ||||||
| UniProtKB:Q503G7 | InterPro | 544 | ||||||
| UniProtKB:A0A8M1N6B8 | InterPro | 551 | ||||||
| UniProtKB:A0AB32T6Q1 | InterPro | 578 | ||||||
| UniProtKB:A0AB32T9G2 | InterPro | 551 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
map3k7-205
(1)
|
Ensembl | 871 nt | ||
| mRNA |
map3k7-201
(1)
|
Ensembl | 4,042 nt | ||
| mRNA |
map3k7-202
(1)
|
Ensembl | 870 nt | ||
| mRNA |
map3k7-203
(1)
|
Ensembl | 820 nt | ||
| mRNA |
map3k7-207
(1)
|
Ensembl | 4,689 nt | ||
| ncRNA |
map3k7-004
(1)
|
Ensembl | 909 nt | ||
| ncRNA |
map3k7-006
(1)
|
Ensembl | 915 nt |
Interactions and Pathways
No data available
Plasmids
No data available