Gene
sel1l
- ID
- ZDB-GENE-041001-122
- Name
- SEL1L adaptor subunit of SYVN1 ubiquitin ligase
- Symbol
- sel1l Nomenclature History
- Previous Names
-
- fj60e07
- si:dkey-177p2.3 (1)
- wu:fj60e07
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; eye; hatching gland; pleuroperitoneal region; and polster. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1578 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Barbieri et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12845 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13871 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14080 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45699 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-sel1l | N/A | Barbieri et al., 2017 |
| MO2-sel1l | N/A | Barbieri et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000562 | Fibronectin type II domain |
| Family | IPR050767 | Sel1/AlgK |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type II domain | Fibronectin type II domain superfamily | Kringle-like fold | Sel1/AlgK | Sel1-like repeat | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RIK6 | InterPro | 776 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-177P2 | ZFIN Curated Data | |
| Encodes | EST | eu1578 | Thisse et al., 2005 | |
| Encodes | EST | fj60e07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045164 (1) | 3560 nt | ||
| Genomic | GenBank:BX248515 (1) | 212105 nt | ||
| Polypeptide | UniProtKB:Q5RIK6 (1) | 776 aa |
- Barbieri, A., Carra, S., De Blasio, P., Cotelli, F., Biunno, I. (2017) Sel1l knockdown negatively influences zebrafish embryos endothelium. Journal of Cellular Physiology. 233(7):5396-5404
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yang, H., Zhou, Y., Gu, J., Xie, S., Xu, Y., Zhu, G., Wang, L., Huang, J., Ma, H., and Yao, J. (2013) Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS One. 8(5):e64058
- Ng, Y.K., Wu, W., and Zhang, L. (2009) Positive correlation between gene coexpression and positional clustering in the zebrafish genome. BMC Genomics. 10:42
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