Gene

cnot3a

ID

ZDB-GENE-040927-6

Name

CCR4-NOT transcription complex, subunit 3a

Symbol

cnot3a Nomenclature History

Previous Names

fb73b06
fc17h07
wu:fb73b06
wu:fc17h07
zgc:92813

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to be involved in negative regulation of translation and nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to localize to CCR4-NOT core complex and P-body. Is expressed in several structures, including gut; head; heart; integument; and testis. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Delacruz et al., 2019

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Delacruz et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnot3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder with speech delay, autism, and dysmorphic facies	618672

Associated With cnot3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007207	CCR4-Not complex component, Not N-terminal domain
Domain	IPR007282	NOT2/NOT3/NOT5, C-terminal
Family	IPR012270	CCR4-NOT complex, subunit 3/ 5
Family	IPR040168	Not2/Not3/Not5
Homologous_superfamily	IPR038635	CCR4-NOT complex subunit 2/3/5, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	CCR4-Not complex component, Not N-terminal domain	CCR4-NOT complex subunit 2/3/5, C-terminal domain superfamily	CCR4-NOT complex, subunit 3/ 5	Not2/Not3/Not5	NOT2/NOT3/NOT5, C-terminal
UniProtKB:E9QGK5 InterPro	901
UniProtKB:F1Q4L8 InterPro	908
UniProtKB:A0A8M9P7W2 InterPro	906

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cnot3a-203 (1) Ensembl	Havana	4198 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cnot3a-003 (1) Ensembl	Havana	634 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations