ZFIN is now using GRCz12tu for Genomic Data
Gene
lyn
- ID
- ZDB-GENE-040912-7
- Name
- LYN proto-oncogene, Src family tyrosine kinase
- Symbol
- lyn Nomenclature History
- Previous Names
-
- zgc:92124
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA cap trimethylguanosine synthase activity. Acts upstream of or within neutrophil chemotaxis; regulation of neutrophil chemotaxis; and response to wounding. Predicted to be active in nucleus. Is expressed in neuromast; post-vent region; and pronephric duct. Orthologous to several human genes including TGS1 (trimethylguanosine synthase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yoo et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yoo et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Autoinflammatory disease, systemic, with vasculitis | 620376 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035748 | Tyrosine-protein kinase Lyn, SH3 domain |
| Domain | IPR035852 | Tyrosine-protein kinase Lyn, SH2 domain |
| Family | IPR019012 | RNA cap guanine-N2 methyltransferase |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RNA cap guanine-N2 methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase Lyn, SH2 domain | Tyrosine-protein kinase Lyn, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66I04 | InterPro | 510 | |||||||||||||||
| UniProtKB:A0A8M2BAN0 | InterPro | 492 | |||||||||||||||
| UniProtKB:A0A8M1RLP2 | InterPro | 800 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers
- Comparative Orthology
- Alliance