Gene

ppifa

ID

ZDB-GENE-040912-52

Name

peptidylprolyl isomerase Fa

Symbol

ppifa Nomenclature History

Previous Names

ppif (1)
wu:fd61c06
zgc:101753

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within protein peptidyl-prolyl isomerization. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to several human genes including PPIA (peptidylprolyl isomerase A); PPIAL4D (peptidylprolyl isomerase A like 4D); and PPIAL4E (peptidylprolyl isomerase A like 4E).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101753 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppifa Human Ortholog

No data available

Associated With ppifa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Domain	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Family	IPR024936	Cyclophilin-type peptidyl-prolyl cis-trans isomerase
Homologous_superfamily	IPR029000	Cyclophilin-like domain superfamily