Gene
serpinf1
- ID
- ZDB-GENE-040912-2
- Name
- serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
- Symbol
- serpinf1 Nomenclature History
- Previous Names
-
- zgc:92072 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of angiogenesis and negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Is expressed in cleithrum; head mesenchyme; notochord; somite; and splanchnocranium. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and non-alcoholic steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136361 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 6 | Alliance | Osteogenesis imperfecta, type VI | 613982 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023795 | Serpin, conserved site |
| Domain | IPR023796 | Serpin domain |
| Domain | IPR033832 | Pigment epithelium derived factor, serpin domain |
| Family | IPR000215 | Serpin family |
| Homologous_superfamily | IPR036186 | Serpin superfamily |
| Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
| Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
| Protein | Length | Pigment epithelium derived factor, serpin domain | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I20
|
406 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpinf1-201
(1)
|
Ensembl | 1,946 nt |
Interactions and Pathways
No data available
Plasmids
No data available